Methanone, specifically the compound with the name "2,4-dihydro-2-methyl-4-[4-(trifluoromethyl)phenyl]-1,2,3-triazolo[4,5-b]indol-7-yl][(3S)-3-hydroxy-1-pyrrolidinyl]-" and CAS number 2738550-24-6, is a complex organic molecule characterized by its unique structural features. It contains a triazole ring fused to an indole moiety, which contributes to its potential biological activity. The presence of a trifluoromethyl group enhances its lipophilicity and may influence its interaction with biological targets. Additionally, the molecule features a pyrrolidine ring with a hydroxyl substituent, which can participate in hydrogen bonding and may affect its solubility and reactivity. The stereochemistry indicated by the (3S) designation suggests specific spatial arrangements that could be crucial for its pharmacological properties. Overall, this compound's intricate structure suggests potential applications in medicinal chemistry, particularly in the development of novel therapeutic agents. However, detailed studies would be necessary to fully elucidate its properties and biological effects.

Methanone, [2,4-dihydro-2-methyl-4-[4-(trifluoromethyl)phenyl]-1,2,3-triazolo[4,5-b]indol-7-yl][(3S)-3-hydroxy-1-pyrrolidinyl]-

2738550-24-6: Methanone, specifically the compound with the name "2,4-dihydro-2-methyl-4-[4-(trifluoromethyl)phenyl]-1,2,3-triazolo[4,5-b]indol-7-yl][(3S)-3-hydroxy-1-pyrrolidinyl]-" and CAS number 2738550-24-6, is a complex organic molecule characterized by its unique structural features. It contains a triazole ring fused to an indole moiety, which contributes to its potential biological activity. The presence of a trifluoromethyl group enhances its lipophilicity and may influence its interaction with biological targets. Additionally, the molecule features a pyrrolidine ring with a hydroxyl substituent, which can participate in hydrogen bonding and may affect its solubility and reactivity. The stereochemistry indicated by the (3S) designation suggests specific spatial arrangements that could be crucial for its pharmacological properties. Overall, this compound's intricate structure suggests potential applications in medicinal chemistry, particularly in the development of novel therapeutic agents. However, detailed studies would be necessary to fully elucidate its properties and biological effects.

<p>M3686 (Compound 29) is a potent and selective TEAD1 inhibitor with an IC50 value of 51 nM. It exhibits weaker binding activity toward TEAD3. M3686 significantly inhibits the cellular activity of YAP-dependent NCI-H226 cell lines, with an IC50 value of 0.06 μM, and demonstrates strong antitumor effects in the NCI-H226 xenograft model.</p>

CAS 2738550-24-6

Methanone, [2,4-dihydro-2-methyl-4-[4-(trifluoromethyl)phenyl]-1,2,3-triazolo[4,5-b]indol-7-yl][(3S)-3-hydroxy-1-pyrrolidinyl]-

M3686

Ref: TM-T205477