The chemical substance with the name "Urea, N-[4-[4-amino-7-(2-hydroxy-2-methylpropyl)-7H-pyrrolo[2,3-d]pyrimidin-5-yl]-2-fluorophenyl]-N'-[4-[(4-methyl-1-piperazinyl)methyl]-3-(trifluoromethyl)phenyl]-" and CAS number 2738569-12-3 is a complex organic compound characterized by its urea functional group, which is central to its structure. This compound features multiple aromatic rings and substituents, including a fluorine atom and a trifluoromethyl group, which can influence its chemical reactivity and biological activity. The presence of a piperazine moiety suggests potential interactions with biological targets, making it of interest in medicinal chemistry. Additionally, the hydroxyl group indicates potential for hydrogen bonding, which can affect solubility and interaction with other molecules. Overall, this compound's intricate structure may confer unique properties, making it a candidate for further research in pharmaceutical applications or as a biochemical probe.

Urea, N-[4-[4-amino-7-(2-hydroxy-2-methylpropyl)-7H-pyrrolo[2,3-d]pyrimidin-5-yl]-2-fluorophenyl]-N'-[4-[(4-methyl-1-piperazinyl)methyl]-3-(trifluoromethyl)phenyl]-

2738569-12-3: The chemical substance with the name "Urea, N-[4-[4-amino-7-(2-hydroxy-2-methylpropyl)-7H-pyrrolo[2,3-d]pyrimidin-5-yl]-2-fluorophenyl]-N'-[4-[(4-methyl-1-piperazinyl)methyl]-3-(trifluoromethyl)phenyl]-" and CAS number 2738569-12-3 is a complex organic compound characterized by its urea functional group, which is central to its structure. This compound features multiple aromatic rings and substituents, including a fluorine atom and a trifluoromethyl group, which can influence its chemical reactivity and biological activity. The presence of a piperazine moiety suggests potential interactions with biological targets, making it of interest in medicinal chemistry. Additionally, the hydroxyl group indicates potential for hydrogen bonding, which can affect solubility and interaction with other molecules. Overall, this compound's intricate structure may confer unique properties, making it a candidate for further research in pharmaceutical applications or as a biochemical probe.

<p>NEK7-IN-1 (Compound I-15) is an inhibitor of NIMA-related kinase 7 (NEK7) with an IC50 of less than 100 nM. It also effectively inhibits the release of IL-1β, exhibiting an IC50 of less than 50 nM.</p>

CAS 2738569-12-3

Urea, N-[4-[4-amino-7-(2-hydroxy-2-methylpropyl)-7H-pyrrolo[2,3-d]pyrimidin-5-yl]-2-fluorophenyl]-N'-[4-[(4-methyl-1-piperazinyl)methyl]-3-(trifluoromethyl)phenyl]-

NEK7-IN-1

Ref: TM-T203437