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CAS 2747914-78-7

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Dexketoprofen-d3 (trometamol)

Description:
Dexketoprofen-d3 (trometamol) is a deuterated form of dexketoprofen, a non-steroidal anti-inflammatory drug (NSAID) primarily used for pain relief and inflammation reduction. As a chiral compound, dexketoprofen is the S-enantiomer of ketoprofen, which enhances its analgesic and anti-inflammatory properties. The "d3" designation indicates that three hydrogen atoms in the molecule have been replaced with deuterium, a stable isotope of hydrogen, which can be useful in pharmacokinetic studies and tracing mechanisms of action. The trometamol salt form improves the solubility and stability of the drug, facilitating its administration. Dexketoprofen-d3 exhibits similar pharmacological effects to its non-deuterated counterpart, including inhibition of cyclooxygenase enzymes, leading to decreased synthesis of prostaglandins, which are mediators of pain and inflammation. Its characteristics include a relatively rapid onset of action, making it effective for acute pain management. As with other NSAIDs, potential side effects may include gastrointestinal discomfort, cardiovascular risks, and renal impairment, necessitating careful consideration in clinical use.
Synonyms:
  • Dexketoprofen-d3 (trometamol)
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