CAS 2752-65-0

Gambogic acid

Description:

Gambogic acid, with the CAS number 2752-65-0, is a natural compound derived from the resin of the Garcinia hanburyi tree, commonly known as gamboge. This yellowish pigment is primarily composed of a complex mixture of polycyclic xanthones. Gambogic acid exhibits a range of biological activities, including anti-inflammatory, antioxidant, and potential anticancer properties, making it of interest in pharmaceutical research. It is characterized by its yellow color and is soluble in organic solvents but has limited solubility in water. The compound has been studied for its effects on various cancer cell lines, showing promise in inhibiting tumor growth. Additionally, gambogic acid has been utilized in traditional medicine, particularly in Southeast Asia, for its therapeutic properties. However, its use is accompanied by caution due to potential toxicity at higher concentrations. Overall, gambogic acid represents a significant area of study in natural product chemistry and its applications in medicine.

Formula: C₃₈H₄₄O₈

InChI: InChI=1/C38H44O8/c1-20(2)10-9-15-36(8)16-14-24-29(39)28-30(40)26-18-23-19-27-35(6,7)46-37(33(23)41,17-13-22(5)34(42)43)38(26,27)45-32(28)25(31(24)44-36)12-11-21(3)4/h10-11,13-14,16,18,23,27,39H,9,12,15,17,19H2,1-8H3,(H,42,43)/b22-13-/t23?,27?,36-,37?,38-/m1/s1

InChI key: InChIKey=GEZHEQNLKAOMCA-RRZNCOCZSA-N

SMILES: C(/C=C(\C(O)=O)/C)[C@@]12[C@]34C(C(=O)C=5C(O3)=C(CC=C(C)C)C6=C(C5O)C=C[C@](CCC=C(C)C)(C)O6)=C[C@@](C1=O)(C[C@]4(C(C)(C)O2)[H])[H]

Synonyms:

• (2Z)-2-Methyl-4-[(1R,3aS,5S,11R,14aS)-3a,4,5,7-tetrahydro-8-hydroxy-3,3,11-trimethyl-13-(3-methyl-2-buten-1-yl)-11-(4-methyl-3-penten-1-yl)-7,15-dioxo-1,5-methano-1H,3H,11H-furo[3,4-g]pyrano[3,2-b]xanthen-1-yl]-2-butenoic acid
• (2Z)-4-[(11R,14aS)-8-hydroxy-3,3,11-trimethyl-13-(3-methylbut-2-en-1-yl)-11-(4-methylpent-3-en-1-yl)-7,15-dioxo-3a,4,5,7-tetrahydro-3H,11H-1,5-methanofuro[3,4-g]pyrano[3,2-b]xanthen-1-yl]-2-methylbut-2-enoic acid
• 1,5-Methano-1H,3H,11H-furo(3,4-g)pyrano(3,2-b)xanthene-1-crotonic acid, 3a,4,5,7-tetrahydro-8-hydroxy-alpha,3,3,11-tetramethyl-13-(3-methyl-2-butenyl)-11-(4-methyl-3-pentenyl)-7,15-dioxo-, (Z)-
• 1,5-Methano-1H,3H,11H-furo[3,4-g]pyrano[3,2-b]xanthene-1-crotonic acid, 3a,4,5,7-tetrahydro-8-hydroxy-α,3,3,11-tetramethyl-13-(3-methyl-2-butenyl)-11-(4-methyl-3-pentenyl)-7,15-dioxo-, (Z)-
• 2-Butenoic acid, 2-methyl-4-[(1R,3aS,5S,11R,14aS)-3a,4,5,7-tetrahydro-8-hydroxy-3,3,11-trimethyl-13-(3-methyl-2-buten-1-yl)-11-(4-methyl-3-penten-1-yl)-7,15-dioxo-1,5-methano-1H,3H,11H-furo[3,4-g]pyrano[3,2-b]xanthen-1-yl]-, (2Z)-
• 2-Butenoic acid, 2-methyl-4-[(1R,3aS,5S,11R,14aS)-3a,4,5,7-tetrahydro-8-hydroxy-3,3,11-trimethyl-13-(3-methyl-2-butenyl)-11-(4-methyl-3-pentenyl)-7,15-dioxo-1,5-methano-1H,3H,11H-furo[3,4-g]pyrano[3,2-b]xanthen-1-yl]-, (2Z)-
• 2-Butenoic acid, 2-methyl-4-[3a,4,5,7-tetrahydro-8-hydroxy-3,3,11-trimethyl-13-(3-methyl-2-butenyl)-11-(4-methyl-3-pentenyl)-7,15-dioxo-1,5-methano-1H,3H,11H-furo[3,4-g]pyrano[3,2-b]xanthen-1-yl]-, [1R-[1α,1(Z),3aβ,5α,11β,14aS*]]-
• B''-Guttiferin
• Cambogic acid
• R-Gambogic acid
• Ui1907
• beta-Guttiferin
• Gambogic acid
• Gambogic acid, 95%, a caspases activator
• 3,3,11-tetramethyl-13-(3-methyl-2-butenyl)-11-(4-7-tetrahydro-8-hydroxy-alph
• Guttic acid
• β-Guttilactone
• B"-Guttiferrin
• Gambogic acid, 97%(HPLC)
• 1,51,5-Methano-1H,3H,11H-furo(3,4-G)pyrano(3,2-B)xanthene-1-crotonic acid
• cambogicacid
• Beta-Guttiferrin
• R,S-Gambogic acid
• alpha-GaMbogic acid
• BETA-GUTTILACTONE
• Guttatic acid
• (z)-methyl-3-pentenyl)-
• GaMbogic aci
• GUTTATIC ACID
• 1,5-methano-1h,3h,11h-furo(3,4-g)pyrano(3,2-b)xanthene-1-crotonicacid,3a,4,5,
• (2Z)-2-Methyl-4-[(1R,3aS,5S,11R,14aS)-3a,4,5,7-tetrahydro-8-hydroxy-3,3,11-trimethyl-13-(3-methyl-2-butenyl)-11-(4-methyl-3-pentenyl)-7,15-dioxo-1,5-methano-1H,3H,11H-furo[3,4-g]pyrano[3,2-b]xanthen-1-yl]-2-butenoicacid
• GUTTIC ACID
• 1,5-Methano-1H,3H,11H-furo(3,4-g)pyrano(3,2-b)xanthene-1-crotonic acid
• Gambogic acid, >=98%

GAMBOGIC ACID

CAS: 2752-65-0

Formula: C₃₈H₄₄O₈

Purity: 97%

Color and Shape: Solid

Molecular weight: 628.7512

Ref: IN-DA00BD9X

Gambogic Acid

CAS: 2752-65-0

Gambogic Acid

Purity: ≥95%

Molecular weight: 628.75g/mol

Ref: 54-BUP10107

Gambogic Acid

CAS: 2752-65-0

Gambogic Acid

Purity: 98%

Molecular weight: 628.75g/mol

Ref: 54-OR1023023

Gambogic acid

CAS: 2752-65-0

Gambogic acid is a tissue-specific proteasome inhibitor, which has anticancer, anti-inflammatory, and anti-angiogenesis activities. Gambogic acid induces LRIG1 (leucine-rich repeat and Ig-like domain-containing-1) upregulation, which is responsible for EGFR (epidermal growth factor receptor) degradation and its downstream Akt/mTORC1 inhibition.

Formula: C₃₈H₄₄O₈

Purity: 95%~99%

Molecular weight: 628.762

Ref: BP-BP0613

Gambogic acid

CAS: 2752-65-0

Formula: C₃₈H₄₄O₈

Purity: ≥ 98.0%

Color and Shape: Yellow to orange powder

Molecular weight: 628.75

Ref: 7W-GL8216

Gambogic Acid

CAS: 2752-65-0

Gambogic Acid (Guttic Acid) ( EC50=0.78-1.64 uM) activates caspases.

Formula: C₃₈H₄₄O₈

Purity: 97.16% - 98.67%

Color and Shape: Solid

Molecular weight: 628.75

Ref: TM-T6185

R,s-gambogic acid

CAS: 2752-65-0

Oxygen-heterocyclic compound

Formula: C₃₈H₄₄O₈

Purity: ≥ 95.0 % (HPLC)

Color and Shape: Powder

Molecular weight: 628.76

Ref: 5G-80455

R-gambogic acid

CAS: 2752-65-0

Oxygen-heterocyclic compound

Formula: C₃₈H₄₄O₈

Purity: ≥ 90.0 % (HPLC)

Color and Shape: Powder

Molecular weight: 628.76

Ref: 5G-85875

Gambogic acid

CAS: 2752-65-0

Gambogic acid is a xanthonoid compound, which is a naturally occurring product derived from the resin of Garcinia hanburyi, a tree found in Southeast Asia. It functions primarily through its apoptotic and anti-proliferative effects on cancer cells. Mechanistically, Gambogic acid binds to transferrin receptors, leading to the disruption of cell survival pathways, inhibition of the NF-kB signaling pathway, and induction of apoptosis by activating caspases and influencing mitochondrial pathways.

Purity: Min. 95%

Ref: 3D-FG42759