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CAS 27536-56-7

:

4alpha-phorbol 12,13-didecanoate

Description:
4α-Phorbol 12,13-didecanoate is a synthetic derivative of phorbol, a naturally occurring compound found in the resin of the Jatropha plant. This chemical is characterized by its structure, which includes a phorbol backbone modified with two decanoate ester groups at the 12 and 13 positions. It is known for its role as a tumor promoter and its ability to activate protein kinase C (PKC), which is involved in various cellular signaling pathways. The compound exhibits lipophilic properties due to the long-chain fatty acid esters, influencing its solubility and biological activity. In laboratory settings, 4α-phorbol 12,13-didecanoate is often used in research to study cell signaling, cancer biology, and the mechanisms of tumor promotion. Safety precautions are necessary when handling this compound, as it can be biologically active and potentially hazardous. Overall, its unique structural features and biological implications make it a significant compound in biochemical research.
Formula:C40H64O8
InChI:InChI=1/C40H64O8/c1-7-9-11-13-15-17-19-21-32(42)47-36-28(4)39(46)30(24-29(26-41)25-38(45)31(39)23-27(3)35(38)44)34-37(5,6)40(34,36)48-33(43)22-20-18-16-14-12-10-8-2/h23-24,28,30-31,34,36,41,45-46H,7-22,25-26H2,1-6H3/t28-,30+,31-,34-,36-,38+,39-,40-/m1/s1
InChI key:InChIKey=DGOSGFYDFDYMCW-OEFRVDPMSA-N
SMILES:O(C(CCCCCCCCC)=O)[C@@]12[C@@](C1(C)C)([C@]3([C@](O)([C@H](C)[C@H]2OC(CCCCCCCCC)=O)[C@]4([C@@](O)(CC(CO)=C3)C(=O)C(C)=C4)[H])[H])[H]
Synonyms:
  • (1aR,1bS,4aS,7aS,7bS,8R,9R,9aS)-4a,7b-dihydroxy-3-(hydroxymethyl)-1,1,6,8-tetramethyl-5-oxo-1,1a,1b,4,4a,5,7a,7b,8,9-decahydro-9aH-cyclopropa[3,4]benzo[1,2-e]azulene-9,9a-diyl didecanoate
  • 1,1′-[(1aR,1bS,4aS,7aS,7bS,8R,9R,9aS)-1,1a,1b,4,4a,5,7a,7b,8,9-Decahydro-4a,7b-dihydroxy-3-(hydroxymethyl)-1,1,6,8-tetramethyl-5-oxo-9aH-cyclopropa[3,4]benz[1,2-e]azulene-9,9a-diyl] didecanoate
  • 4a-Phorbol-12,13-didecanoate
  • 4α-PDD
  • 4α-Phorbol didecanoate
  • 5H-Cyclopropa[3,4]benz[1,2-e]azulen-5-one, 1,1aα,1bβ,4,4a,7aα,7b,8,9,9a-decahydro-4aα,7bα,9β,9aα-tetrahydroxy-3-(hydroxymethyl)-1,1,6,8α-tetramethyl-, 9,9a-didecanoate
  • 9aH-Cyclopropa[3,4]benz[1,2-e]azulene, decanoic acid deriv.
  • Decanoic acid, (1aR,1bS,4aS,7aS,7bS,8R,9R,9aS)-1,1a,1b,4,4a,5,7a,7b,8,9-decahydro-4a,7b-dihydroxy-3-(hydroxymethyl)-1,1,6,8-tetramethyl-5-oxo-9aH-cyclopropa[3,4]benz[1,2-e]azulene-9,9a-diyl ester
  • Decanoic acid, 1,1a,1b,4,4a,5,7a,7b,8,9-decahydro-4a,7b-dihydroxy-3-(hydroxymethyl)-1,1,6,8-tetramethyl-5-oxo-9aH-cyclopropa[3,4]benz[1,2-e]azulene-9,9a-diyl ester, [1aR-(1aα,1bβ,4aα,7aα,7bα,8α,9β,9aα)]-
  • Decanoic acid, 1,1′-[(1aR,1bS,4aS,7aS,7bS,8R,9R,9aS)-1,1a,1b,4,4a,5,7a,7b,8,9-decahydro-4a,7b-dihydroxy-3-(hydroxymethyl)-1,1,6,8-tetramethyl-5-oxo-9aH-cyclopropa[3,4]benz[1,2-e]azulene-9,9a-diyl] ester
  • See more synonyms
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Found 4 products.
  • 4α-Phorbol 12,13-didecanoate
    Glentham
    + Info

    4α-Phorbol 12,13-didecanoate

    CAS:
    Formula:C40H64O8
    Molecular weight:672.93

    Ref: 7W-GL3242

    ne
    To inquire
  • 4α-Phorbol 12,13-didecanoate
    TRC
    + Info

    4α-Phorbol 12,13-didecanoate

    Controlled Product
    CAS:

    Applications 4α-Phorbol 12,13-didecanoate is an activator of TRPV4.
    Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package

    Formula:C40H64O8
    Color and Shape:Neat
    Molecular weight:672.93

    Ref: TR-P353498

    1mg
    354.00€
  • 4±-Phorbol 12,13-didecanoate
    Biosynth
    + Info

    4±-Phorbol 12,13-didecanoate

    CAS:

    4α-Phorbol 12,13-didecanoate is a chemical compound known as a phorbol ester, which is derived from croton oil. This compound is part of a class of diterpene esters and is primarily utilized in scientific research due to its role as a potent activator of protein kinase C (PKC).

    Formula:C40H64O8
    Purity:Min. 95%
    Molecular weight:672.93 g/mol

    Ref: 3D-CBA53656

    25mg
    4,095.00€
    50mg
    5,850.00€
    100mg
    8,891.00€
    250mg
    18,426.00€
    500mg
    29,247.00€
  • 4α-PDD
    Targetmol
    + Info

    4α-PDD

    CAS:
    4alpha-PDD activates transient receptor potential vanilloid 4 (TRPV4) channels and is inactive for signaling through PKC.
    Formula:C40H64O8
    Color and Shape:Solid
    Molecular weight:672.93

    Ref: TM-T26386

    1mg
    325.00€
    5mg
    1,378.00€