CAS 27536-56-7: 4alpha-phorbol 12,13-didecanoate

Description: 4α-Phorbol 12,13-didecanoate is a synthetic derivative of phorbol, a naturally occurring compound found in the resin of the Jatropha plant. This chemical is characterized by its structure, which includes a phorbol backbone modified with two decanoate ester groups at the 12 and 13 positions. It is known for its role as a tumor promoter and its ability to activate protein kinase C (PKC), which is involved in various cellular signaling pathways. The compound exhibits lipophilic properties due to the long-chain fatty acid esters, influencing its solubility and biological activity. In laboratory settings, 4α-phorbol 12,13-didecanoate is often used in research to study cell signaling, cancer biology, and the mechanisms of tumor promotion. Safety precautions are necessary when handling this compound, as it can be biologically active and potentially hazardous. Overall, its unique structural features and biological implications make it a significant compound in biochemical research.

Formula: C₄₀H₆₄O₈

InChI: InChI=1S/C40H64O8/c1-7-9-11-13-15-17-19-21-32(42)47-36-28(4)39(46)30(24-29(26-41)25-38(45)31(39)23-27(3)35(38)44)34-37(5,6)40(34,36)48-33(43)22-20-18-16-14-12-10-8-2/h23-24,28,30-31,34,36,41,45-46H,7-22,25-26H2,1-6H3/t28-,30+,31-,34-,36-,38+,39-,40-/m1/s1

InChI key: InChIKey=DGOSGFYDFDYMCW-OEFRVDPMSA-N

SMILES: O=C(OC1C(C)C2(O)C(C=C(CO)CC3(O)C(=O)C(=CC32)C)C4C1(OC(=O)CCCCCCCCC)C4(C)C)CCCCCCCCC

Synonyms:

• (1aR,1bS,4aS,7aS,7bS,8R,9R,9aS)-4a,7b-dihydroxy-3-(hydroxymethyl)-1,1,6,8-tetramethyl-5-oxo-1,1a,1b,4,4a,5,7a,7b,8,9-decahydro-9aH-cyclopropa[3,4]benzo[1,2-e]azulene-9,9a-diyl didecanoate
• 1,1′-[(1aR,1bS,4aS,7aS,7bS,8R,9R,9aS)-1,1a,1b,4,4a,5,7a,7b,8,9-Decahydro-4a,7b-dihydroxy-3-(hydroxymethyl)-1,1,6,8-tetramethyl-5-oxo-9aH-cyclopropa[3,4]benz[1,2-e]azulene-9,9a-diyl] didecanoate
• 4a-Phorbol-12,13-didecanoate
• 4α-PDD
• 4α-Phorbol didecanoate
• 5H-Cyclopropa[3,4]benz[1,2-e]azulen-5-one, 1,1aα,1bβ,4,4a,7aα,7b,8,9,9a-decahydro-4aα,7bα,9β,9aα-tetrahydroxy-3-(hydroxymethyl)-1,1,6,8α-tetramethyl-, 9,9a-didecanoate
• 9aH-Cyclopropa[3,4]benz[1,2-e]azulene, decanoic acid deriv.
• Decanoic acid, (1aR,1bS,4aS,7aS,7bS,8R,9R,9aS)-1,1a,1b,4,4a,5,7a,7b,8,9-decahydro-4a,7b-dihydroxy-3-(hydroxymethyl)-1,1,6,8-tetramethyl-5-oxo-9aH-cyclopropa[3,4]benz[1,2-e]azulene-9,9a-diyl ester
• Decanoic acid, 1,1a,1b,4,4a,5,7a,7b,8,9-decahydro-4a,7b-dihydroxy-3-(hydroxymethyl)-1,1,6,8-tetramethyl-5-oxo-9aH-cyclopropa[3,4]benz[1,2-e]azulene-9,9a-diyl ester, [1aR-(1aα,1bβ,4aα,7aα,7bα,8α,9β,9aα)]-
• Decanoic acid, 1,1′-[(1aR,1bS,4aS,7aS,7bS,8R,9R,9aS)-1,1a,1b,4,4a,5,7a,7b,8,9-decahydro-4a,7b-dihydroxy-3-(hydroxymethyl)-1,1,6,8-tetramethyl-5-oxo-9aH-cyclopropa[3,4]benz[1,2-e]azulene-9,9a-diyl] ester
• Decanoic acid, 9,9a-diester with 1,1aα,1bβ,4,4a,7aα,7b,8,9,9a-decahydro-4aα,7bα,9β,9aα-tetrahydroxy-3-(hydroxymethyl)-1,1,6,8α-tetramethyl-5H-cyclopropa[3,4]benz[1,2-e]azulen-5-one

4α-Phorbol 12,13-didecanoate

CAS: 27536-56-7

• Formula: C₄₀H₆₄O₈
• Molecular weight: 672.93

4α-Phorbol 12,13-didecanoate

CAS: 27536-56-7

Applications 4α-Phorbol 12,13-didecanoate is an activator of TRPV4. Not a dangerous good if item is …

• Formula: C₄₀H₆₄O₈
• Color and Shape: Neat
• Molecular weight: 672.93

4±-Phorbol 12,13-didecanoate

CAS: 27536-56-7

Please enquire for more information about 4±-Phorbol 12,13-didecanoate including the price, delivery time and more …

• Formula: C₄₀H₆₄O₈
• Purity: Min. 95%
• Molecular weight: 672.93 g/mol

4α-PDD

CAS: 27536-56-7

4alpha-PDD activates transient receptor potential vanilloid 4 (TRPV4) channels and is inactive for signaling through …

• Formula: C₄₀H₆₄O₈
• Color and Shape: Solid
• Molecular weight: 672.93