CAS 27548-93-2
:Baccatin III
Description:
Baccatin III is a naturally occurring chemical compound classified as a diterpene, specifically a taxane, and is primarily derived from the Pacific yew tree (Taxus brevifolia). It is known for its structural complexity, featuring a unique bicyclic core that is characteristic of taxanes. Baccatin III serves as a crucial precursor in the synthesis of the anticancer drug paclitaxel (Taxol), which is used in the treatment of various cancers, including ovarian and breast cancer. The compound exhibits significant biological activity, particularly in its ability to stabilize microtubules and inhibit cell division, making it a valuable subject of research in medicinal chemistry. Baccatin III is typically characterized by its molecular formula, which reflects its composition of carbon, hydrogen, and oxygen atoms. Its solubility properties and stability under various conditions are also of interest in pharmaceutical applications. Overall, Baccatin III plays a vital role in the development of therapeutic agents and continues to be studied for its potential in cancer treatment and other medical applications.
Formula:C31H38O11
InChI:InChI=1S/C31H38O11/c1-15-19(34)13-31(38)26(41-27(37)18-10-8-7-9-11-18)24-29(6,20(35)12-21-30(24,14-39-21)42-17(3)33)25(36)23(40-16(2)32)22(15)28(31,4)5/h7-11,19-21,23-24,26,34-35,38H,12-14H2,1-6H3/t19-,20-,21+,23+,24-,26-,29+,30-,31+/m0/s1
InChI key:InChIKey=OVMSOCFBDVBLFW-VHLOTGQHSA-N
SMILES:O(C(C)=O)[C@]12[C@]3([C@H](OC(=O)C4=CC=CC=C4)[C@@]5(O)C(C)(C)C([C@@H](OC(C)=O)C(=O)[C@]3(C)[C@@H](O)C[C@]1(OC2)[H])=C(C)[C@@H](O)C5)[H]
Synonyms:- (1Beta,2Alpha,5Beta,7Beta,10Alpha,13Alpha)-4,10-Bis(Acetyloxy)-1,7,13-Trihydroxy-9-Oxo-5,20-Epoxytax-11-En-2-Yl Benzoate
- (2Alpha,3Beta,5Beta,7Beta,10Beta,13Alpha)-4,10-Bis(Acetyloxy)-1,7,13-Trihydroxy-9-Oxo-5,20-Epoxytax-11-En-2-Yl Benzoate
- (2Alpha,3Xi,5Beta,7Beta,10Beta,13Alpha)-4,10-Bis(Acetyloxy)-1,7,13-Trihydroxy-9-Oxo-5,20-Epoxytax-11-En-2-Yl Benzoatato
- (2Alpha,5Beta,7Beta,10Beta,13Alpha)-4,10-Bis(Acetyloxy)-1,7,13-Trihydroxy-9-Oxo-5,20-Epoxytax-11-En-2-Yl Benzoate
- (2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-6,12b-Bis(acetyloxy)-12-(benzoyloxy)-1,2a,3,4,4a,6,9,10,11,12,12a,12b-dodecahydro-4,9,11-trihydroxy-4a,8,13,13-tetramethyl-7,11-methano-5H-cyclodeca[3,4]benz[1,2-b]oxet-5-one
- 7,11-Methano-5H-cyclodeca[3,4]benz[1,2-b]oxet-5-one, 6,12b-bis(acetyloxy)-12-(benzoyloxy)-1,2a,3,4,4a,6,9,10,11,12,12a,12b-dodecahydro-4,9,11-trihydroxy-4a,8,13,13-tetramethyl-, (2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-
- 7,11-Methano-5H-cyclodeca[3,4]benz[1,2-b]oxet-5-one, 6,12b-bis(acetyloxy)-12-(benzoyloxy)-1,2a,3,4,4a,6,9,10,11,12,12a,12b-dodecahydro-4,9,11-trihydroxy-4a,8,13,13-tetramethyl-, [2aR-(2aα,4β,4aβ,6β,9α,11α,12α,12aα,12bα)]-
- Baccatin III
- NSC 330753
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Found 13 products.
Baccatin III
CAS:<p>Baccatin III: polycyclic diterpene for semi-synthetic paclitaxel, with immunomodulatory and anticancer properties.</p>Formula:C31H38O11Purity:98.45%Color and Shape:White To Off-White PowderMolecular weight:586.63Paclitaxel EP Impurity N (Baccatin III)
CAS:Formula:C31H38O11Color and Shape:White To Off-White SolidMolecular weight:586.63Baccatin III
CAS:Formula:C31H38O11Purity:≥ 98.0%Color and Shape:White to off-white powderMolecular weight:586.63Baccatin III
CAS:Baccatin III, which is the precursor for the semisynthesis of paclitaxel,exerts anti-tumor immunomodulatory activity in very low doses (0.05-0.5mg/kg),it reduces tumor progression by inhibiting the accumulation and suppressive function of MDSCs. Baccatin III also exerts immunomodulatory activities in vivo as well as in vitro on the MHC-restricted antigen presentation.Formula:C31H38O11Purity:95%~99%Molecular weight:586.634Paclitaxel EP Impurity N
CAS:Controlled ProductFormula:C31H38O11Color and Shape:NeatMolecular weight:586.63Baccatin iii
CAS:Oxygen-heterocyclic compoundFormula:C31H38O11Purity:≥ 95.0 % (HPLC)Color and Shape:PowderMolecular weight:586.64Baccatin III
CAS:Controlled Product<p>Impurity Paclitaxel - Impurity N<br>Applications A precursor to Paclitaxel, a neoplasm inhibitor to ovarian and breast cancers found in Taxus species. Paclitaxel - Impurity N.<br>References Katkovcinova, Z., et al.: J. Biosci., 63, 721 (2008), Tian, J., et al.: J. Pharm. Sci., 97, 3100 (2008), Miao, Z., et al.: App. Biochem. Microbiol., 45, 81 (2009),<br></p>Formula:C31H38O11Color and Shape:NeatMolecular weight:586.63Baccatin III
CAS:<p>Baccatin III is a naturally occurring diterpenoid compound, which is sourced from the needles of the European yew tree, *Taxus baccata*. This plant-based compound serves as a crucial precursor in the biosynthesis and semi-synthesis of paclitaxel, a chemotherapeutic agent widely used in cancer treatment. The mode of action of baccatin III involves its transformation into more active drug forms, such as paclitaxel and docetaxel, both of which function by stabilizing microtubules and thus inhibiting cell division.</p>Formula:C31H38O11Purity:Min. 97.5 Area-%Color and Shape:White PowderMolecular weight:586.63 g/molBaccatin III ((2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-12-(Benzoyloxy)-4,9,11-trihydroxy-4a,8,13,13-tetramethyl-5-oxo-3,4,4a,5,6,9,10,11,12,12a-decahydro-1H-7,11-methanocyclodeca[3,4]benzo[1,2-b]oxete-6,12b(2aH)-diyl diacetate)
CAS:Aromatic heterocyclic compounds with oxygen hetero-atom(s) only, nesoiFormula:C31H38O11Color and Shape:White SolidMolecular weight:586.241417,11-Methano-5H-cyclodeca[3,4]benz[1,2-b]oxet-5-one, 6,12b-bis(acetyloxy)-12-(benzoyloxy)-1,2a,3,4,4a,6,9,10,11,12,12a,12b-dodecahydro-4,9,11-trihydroxy-4a,8,13,13-tetramethyl-, (2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-
CAS:Formula:C31H38O11Color and Shape:SolidMolecular weight:586.6268
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