CAS 2756-87-8

Monomethyl fumarate

Description:

Monomethyl fumarate (MMF) is an organic compound characterized by its structure as a methyl ester of fumaric acid. It is a colorless to pale yellow liquid with a slightly sweet odor and is soluble in polar solvents such as water and alcohols. MMF is known for its role in the treatment of multiple sclerosis, where it acts as an immunomodulatory agent. The compound exhibits a double bond in its structure, contributing to its reactivity and potential for undergoing various chemical transformations. It has a relatively low molecular weight and is classified as a dicarboxylic acid derivative. In terms of safety, MMF should be handled with care, as it may cause skin and eye irritation upon contact. Its stability is influenced by environmental factors, and it is typically stored in a cool, dry place to maintain its integrity. Overall, monomethyl fumarate is significant in both pharmaceutical applications and chemical research due to its unique properties and biological activity.

Formula: C₅H₆O₄

InChI: InChI=1S/C5H6O4/c1-9-5(8)3-2-4(6)7/h2-3H,1H3,(H,6,7)/b3-2+

InChI key: InChIKey=NKHAVTQWNUWKEO-NSCUHMNNSA-N

SMILES: C(/C=C/C(O)=O)(OC)=O

Synonyms:

• (2E)-4-methoxy-4-oxobut-2-enoic acid
• (2Z)-4-methoxy-4-oxobut-2-enoic acid
• (E)-4-Methoxy-4-oxo-but-2-enoic acid
• (E)-4-Methoxy-4-oxobut-2-enoic acid
• 2-Butenedioic acid (2E)-, 1-methyl ester
• 2-Butenedioic acid (2E)-, monomethyl ester
• 2-Butenedioic acid (E)-, monomethyl ester
• Fumaric acid monomethyl ester
• Fumaric acid, methyl ester
• Methyl hydrogen fumarate

Monomethyl Fumarate

CAS: 2756-87-8

Formula: C₅H₆O₄

Purity: >98.0%(GC)

Color and Shape: White to Almost white powder to crystal

Molecular weight: 130.10

Ref: 3B-M2413

Dimethyl Fumarate Related Compound A ((E)-4-Methoxy-4-oxobut-2-enoic acid)

CAS: 2756-87-8

Acyclic polycarboxylic acids and their anhydrides, halides, peroxides and their derivatives, nesoi

Formula: C₅H₆O₄

Color and Shape: White Powder

Molecular weight: 130.02661

Ref: 45-1210229

2-Butenedioic acid (2E)-, 1-methyl ester

CAS: 2756-87-8

Formula: C₅H₆O₄

Purity: 98%

Color and Shape: Solid

Molecular weight: 130.0987

Ref: IN-DA002U2G

Monomethyl fumarate

CAS: 2756-87-8

Monomethyl fumarate is a potent agonist of GPR109A .

Formula: C₅H₆O₄

Purity: 99.21%

Color and Shape: Solid

Molecular weight: 130.1

Ref: TM-T12095

mono-Methyl fumarate

CAS: 2756-87-8

mono-Methyl fumarate

Formula: C₅H₆O₄

Purity: 98%

Color and Shape: white solid

Molecular weight: 130.10g/mol

Ref: 54-OR59971

Dimethyl Fumarate USP Related Compound A (Monomethyl Fumarate)

CAS: 2756-87-8

Formula: C₅H₆O₄

Color and Shape: White To Off-White Solid

Molecular weight: 130.10

Ref: 4Z-F-555

Monomethyl fumarate

CAS: 2756-87-8

Monomethyl fumarate

Purity: ≥98%

Molecular weight: 130.1g/mol

Ref: 54-BUP18092

mono-Methyl fumarate

CAS: 2756-87-8

Formula: C₅H₆O₄

Purity: ≥ 97%

Color and Shape: White to off-white powder or solid

Molecular weight: 130.10

Ref: 7W-GX0227

Dimethyl Fumarate USP Related Compound A (Monomethyl Fumarate)

Controlled Product

CAS: 2756-87-8

Formula: C₅H₆O₄

Color and Shape: Neat

Molecular weight: 130.10

Ref: 86-MM0352.03

Mono-Methyl fumarate

CAS: 2756-87-8

Purity: 99.0%

Color and Shape: Solid

Molecular weight: 130.026608672

Ref: 10-F094823

Diroximel Impurity C

CAS: 2756-87-8

Formula: C₅H₆O₄

Molecular weight: 130.1

Ref: ST-EA-CP-D109006

Fumaric Acid Monomethyl Ester

Controlled Product

CAS: 2756-87-8

Applications Fumaric Acid Monomethyl Ester is one of the most bioactive anti-psoriatic fumaric acid ester metabolite. Fumaric acid monomethyl ester is potent nicotinic acid receptor agonist. Fumaric acid monomethyl ester has also been shown to selectively stimulate of T helper 2 cytokine response. It is also the active metabolite of Dimethyl Fumarate (D464965), a compound that is used as a treatment for the relapsing forms of multiple sclerosis and psoriasis.
References de Jong, R. et al.: Eur. J. Immunol., 26, 2067 (1996); Litjens, N.H.R. et al.: Br. J. Dermatol., 154, 211 (2006); Schimrigk, S., et al.: Eur. J. Neurol., 13, 604 (2006); Tang, H. et al.: Biochem. Biophys. Res. Comm., 375, 562 (2008)

Formula: C₅H₆O₄

Color and Shape: Neat

Molecular weight: 130.10

Ref: TR-F500390

Monomethyl fumarate

CAS: 2756-87-8

Monomethyl fumarate is a metabolite of dimethyl fumarate (DMF) and has been shown to be an inhibitor of the mitochondrial membrane potential. DMF is currently in clinical trials for the treatment of bowel disease, but its use has been limited by its poor oral bioavailability. Monomethyl fumarate has been shown to be more potent than DMF in inhibiting mitochondrial membrane potential and, therefore, may be a better therapeutic candidate for the treatment of bowel disease. Monomethyl fumarate also inhibits cell lysis through inhibition of tiglic acid production and increased resistance to autoimmune diseases.

Formula: C₅H₆O₄

Purity: Min. 98 Area-%

Color and Shape: White Off-White Powder

Molecular weight: 130.1 g/mol

Ref: 3D-FM40408