CAS 2756978-82-0

2,4-Pyrimidinediamine, 5-bromo-N4-[2-(dimethylphosphinyl)-4-methylphenyl]-N2-[2-methoxy-5-methyl-4-[4-(4-methyl-1-piperazinyl)-1-piperidinyl]phenyl]-

Description:

2,4-Pyrimidinediamine, 5-bromo-N4-[2-(dimethylphosphinyl)-4-methylphenyl]-N2-[2-methoxy-5-methyl-4-[4-(4-methyl-1-piperazinyl)-1-piperidinyl]phenyl]- is a complex organic compound characterized by its multi-functional structure, which includes a pyrimidine ring, multiple aromatic systems, and various substituents that enhance its chemical reactivity and potential biological activity. The presence of bromine suggests it may participate in electrophilic substitution reactions, while the dimethylphosphinyl group indicates potential applications in medicinal chemistry, particularly in the development of pharmaceuticals. The compound's piperazine and piperidine moieties may contribute to its interaction with biological targets, possibly influencing its pharmacokinetic properties. Additionally, the methoxy and methyl groups can affect solubility and lipophilicity, which are critical for drug design. Overall, this compound's intricate structure suggests it may exhibit unique properties, making it of interest in research areas such as drug development and agrochemicals. However, specific biological activity and safety profiles would require further investigation through empirical studies.

Formula: C₃₁H₄₃BrN₇O₂P

Synonyms:

• 2,4-Pyrimidinediamine, 5-bromo-N4-[2-(dimethylphosphinyl)-4-methylphenyl]-N2-[2-methoxy-5-methyl-4-[4-(4-methyl-1-piperazinyl)-1-piperidinyl]phenyl]-

DA-0157

CAS: 2756978-82-0

DA-0157 is an orally active inhibitor targeting EGFR and ALK, designed to overcome resistance mutations in non-small cell lung cancer (NSCLC). It effectively inhibits the proliferation of Ba/F3-EGFR Del19/T790M/C797S (IC50= 6.9 nM), Ba/F3-EGFR WT (IC50= 0.83 μM), Ba/F3-EML4-ALK-L1196M (IC50= 5.5 nM), and Ba/F3-EML4-ALK (IC50= 7.4 nM). Additionally, DA-0157 inhibits CYP2D6 with an IC50 of 5.26 μM and demonstrates antitumor activity in mouse models.

Formula: C₃₁H₄₃BrN₇O₂P

Color and Shape: Solid

Molecular weight: 656.597

Ref: TM-T205118