CAS 2758114-60-0

Tubulin polymerization-IN-61

Description:

Tubulin polymerization-IN-61, identified by its CAS number 2758114-60-0, is a small molecule that acts as an inhibitor of tubulin polymerization, which is a critical process in cell division and the formation of the cytoskeleton. This compound is part of a class of agents that target microtubules, thereby disrupting their dynamics and potentially leading to anti-cancer effects by preventing mitotic spindle formation. Characteristically, it exhibits a specific binding affinity for tubulin, which can alter the normal function of microtubules in cellular processes. The compound's efficacy and mechanism of action are typically evaluated through biochemical assays and cellular models, where its impact on cell proliferation and apoptosis can be assessed. Additionally, its pharmacokinetic properties, such as solubility, stability, and bioavailability, are crucial for determining its potential therapeutic applications. Overall, Tubulin polymerization-IN-61 represents a promising avenue for research in cancer therapeutics, particularly in the context of targeting the cytoskeletal components of rapidly dividing cells.

Formula: C₂₂H₂₁N₃O₅

Synonyms:

• Tubulin polymerization-IN-61

Tubulin polymerization-IN-61

CAS: 2758114-60-0

Tubulin polymerization-IN-61 (Compound 9a), a tubulin polymerization inhibitor, disrupts the microtubule skeleton, arrests the cell cycle at the G2/M phase, induces Apoptosis, and impedes cancer cell migration and colony formation. This compound demonstrates antitumor efficacy in vivo within the 4T1 xenograft model [1].

Formula: C₂₂H₂₁N₃O₅

Color and Shape: Solid

Molecular weight: 407.42

Ref: TM-T87579