CAS 2758666-01-0

1,2,4-Oxadiazol-5(2H)-one, 3-[1-[2-[[(4S)-3-[3-(4-fluoro-1-methyl-1H-indazol-5-yl)-2,3-dihydro-2-oxo-1H-imidazol-1-yl]-2-(4-fluorophenyl)-6,7-dihydro-4-methylpyrazolo[1,5-a]pyrazin-5(4H)-yl]carbonyl]-6-[(4R)-tetrahydro-2,2-dimethyl-2H-pyran-4-yl]-1-indolizinyl]cyclopropyl]-

Description:

1,2,4-Oxadiazol-5(2H)-one derivatives, such as the compound with CAS number 2758666-01-0, typically exhibit a range of interesting chemical and biological properties. This specific compound features a complex structure that includes multiple heterocycles, which can enhance its reactivity and potential pharmacological activity. The presence of functional groups such as carbonyls and fluorinated moieties often contributes to increased lipophilicity and bioavailability, making such compounds of interest in medicinal chemistry. The oxadiazole ring is known for its stability and ability to participate in various chemical reactions, including nucleophilic substitutions and cycloadditions. Additionally, the incorporation of indolizinyl and pyrazolo moieties may impart unique biological activities, potentially leading to applications in drug development. Overall, compounds of this nature are often investigated for their potential as therapeutic agents, particularly in areas such as oncology or infectious diseases, due to their diverse structural features and the ability to interact with biological targets.

Formula: C₄₅H₄₂F₂N₁₀O₅

Synonyms:

• 1,2,4-Oxadiazol-5(2H)-one, 3-[1-[2-[[(4S)-3-[3-(4-fluoro-1-methyl-1H-indazol-5-yl)-2,3-dihydro-2-oxo-1H-imidazol-1-yl]-2-(4-fluorophenyl)-6,7-dihydro-4-methylpyrazolo[1,5-a]pyrazin-5(4H)-yl]carbonyl]-6-[(4R)-tetrahydro-2,2-dimethyl-2H-pyran-4-yl]-1-indolizinyl]cyclopropyl]-
• GLP-1R agonist 14

GLP-1R agonist 14

CAS: 2758666-01-0

GLP-1R agonist 14, also known as Compound 14, is a potent agonist of the GLP-1 receptor, demonstrating an EC50 range of 0-20 nM against human GLP-1 [1].

Formula: C₄₅H₄₂F₂N₁₀O₅

Color and Shape: Solid

Molecular weight: 840.88

Ref: TM-T74608