CAS 27589-33-9: Azosemide
Description:Azosemide is a chemical compound classified as a loop diuretic, primarily used in the treatment of conditions such as edema associated with heart failure and hypertension. It functions by inhibiting the sodium-potassium-chloride co-transporter in the thick ascending limb of the loop of Henle in the kidneys, leading to increased excretion of sodium, chloride, and water. This mechanism results in diuresis, helping to reduce fluid overload in patients. Azosemide is characterized by its relatively high solubility in water, which facilitates its administration and absorption in the body. The compound has a specific chemical structure that contributes to its pharmacological activity, and it is often administered orally or intravenously, depending on the clinical scenario. As with other diuretics, potential side effects may include electrolyte imbalances, dehydration, and renal function impairment, necessitating careful monitoring during treatment. Overall, azosemide is an important therapeutic agent in managing fluid retention and hypertension, particularly in patients with cardiovascular conditions.
Formula:C12H11ClN6O2S2
InChI:InChI=1S/C12H11ClN6O2S2/c13-9-5-10(15-6-7-2-1-3-22-7)8(12-16-18-19-17-12)4-11(9)23(14,20)21/h1-5,15H,6H2,(H2,14,20,21)(H,16,17,18,19)
InChI key:InChIKey=HMEDEBAJARCKCT-UHFFFAOYSA-N
SMILES:O=S(=O)(N)C1=CC(C2=NN=NN2)=C(C=C1Cl)NCC=3SC=CC3
- Synonyms:
- 2-Chloro-5-(1H-tetrazol-5-yl)-4-[(2-thienylmethyl)amino]benzenesulfonamide
- 2-Chloro-5-(2H-tetrazol-5-yl)-4-(thiophen-2-ylmethylamino)benzenesulfonamide
- 2-Chloro-5-(2H-tetrazol-5-yl)-4-[(2-thienylmethyl)amino]benzenesulfonamide
- 2-Chloro-5-(2H-tetrazol-5-yl)-N4-2-thenylsulfanilamide
- 2-chloro-5-(1H-tetrazol-5-yl)-4-[(thiophen-2-ylmethyl)amino]benzenesulfonamide
- 2-chloro-5-(2H-tetrazol-5-yl)-4-[(thiophen-2-ylmethyl)amino]benzenesulfonamide
- 248-549-7
- 5-(4'-Chloro-2'-thenylamino-5'-sulfamoylphenyl)tetrazole
- 5-(4-Chloro-5-sulfamoyl-2-thenylaminophenyl)tetrazole
- Benzenesulfonamide, 2-chloro-5-(2H-tetrazol-5-yl)-4-[(2-thienylmethyl)amino]-
- See more synonyms
- Diart
- Diurapid
- Luret
- Ple 1053
- SK 110 (pharmaceutical)
- Sk 110
- Sulfanilamide, 2-chloro-5-(1H-tetrazol-5-yl)-N<sup>4</sup>-2-thenyl-
- benzenesulfonamide, 2-chloro-5-(1H-tetrazol-5-yl)-4-[(2-thienylmethyl)amino]-
- Sulfanilamide, 2-chloro-5-(1H-tetrazol-5-yl)-N4-2-thenyl-