CAS 27589-33-9: Azosemide

Description: Azosemide is a chemical compound classified as a loop diuretic, primarily used in the treatment of conditions such as edema associated with heart failure and hypertension. It functions by inhibiting the sodium-potassium-chloride co-transporter in the thick ascending limb of the loop of Henle in the kidneys, leading to increased excretion of sodium, chloride, and water. This mechanism results in diuresis, helping to reduce fluid overload in patients. Azosemide is characterized by its relatively high solubility in water, which facilitates its administration and absorption in the body. The compound has a specific chemical structure that contributes to its pharmacological activity, and it is often administered orally or intravenously, depending on the clinical scenario. As with other diuretics, potential side effects may include electrolyte imbalances, dehydration, and renal function impairment, necessitating careful monitoring during treatment. Overall, azosemide is an important therapeutic agent in managing fluid retention and hypertension, particularly in patients with cardiovascular conditions.

Formula: C₁₂H₁₁ClN₆O₂S₂

InChI: InChI=1S/C12H11ClN6O2S2/c13-9-5-10(15-6-7-2-1-3-22-7)8(12-16-18-19-17-12)4-11(9)23(14,20)21/h1-5,15H,6H2,(H2,14,20,21)(H,16,17,18,19)

InChI key: InChIKey=HMEDEBAJARCKCT-UHFFFAOYSA-N

SMILES: O=S(=O)(N)C1=CC(C2=NN=NN2)=C(C=C1Cl)NCC=3SC=CC3

Synonyms:

• 2-Chloro-5-(1H-tetrazol-5-yl)-4-[(2-thienylmethyl)amino]benzenesulfonamide
• 2-Chloro-5-(2H-tetrazol-5-yl)-4-(thiophen-2-ylmethylamino)benzenesulfonamide
• 2-Chloro-5-(2H-tetrazol-5-yl)-4-[(2-thienylmethyl)amino]benzenesulfonamide
• 2-Chloro-5-(2H-tetrazol-5-yl)-N4-2-thenylsulfanilamide
• 2-chloro-5-(1H-tetrazol-5-yl)-4-[(thiophen-2-ylmethyl)amino]benzenesulfonamide
• 2-chloro-5-(2H-tetrazol-5-yl)-4-[(thiophen-2-ylmethyl)amino]benzenesulfonamide
• 248-549-7
• 5-(4'-Chloro-2'-thenylamino-5'-sulfamoylphenyl)tetrazole
• 5-(4-Chloro-5-sulfamoyl-2-thenylaminophenyl)tetrazole
• Benzenesulfonamide, 2-chloro-5-(2H-tetrazol-5-yl)-4-[(2-thienylmethyl)amino]-
• Diart
• Diurapid
• Luret
• Ple 1053
• SK 110 (pharmaceutical)
• Sk 110
• Sulfanilamide, 2-chloro-5-(1H-tetrazol-5-yl)-N⁴-2-thenyl-
• benzenesulfonamide, 2-chloro-5-(1H-tetrazol-5-yl)-4-[(2-thienylmethyl)amino]-
• Sulfanilamide, 2-chloro-5-(1H-tetrazol-5-yl)-N4-2-thenyl-

Benzenesulfonamide, 2-chloro-5-(2H-tetrazol-5-yl)-4-[(2-thienylmethyl)amino]-

CAS: 27589-33-9

• Formula: C₁₂H₁₁ClN₆O₂S₂
• Purity: 97%
• Color and Shape: Solid
• Molecular weight: 370.8377

Azosemide

CAS: 27589-33-9

Azosemide is a potent NKCC1 inhibitor (IC50s: 0.246 µM and 0.197 µM for hNKCC1A and …

• Formula: C₁₂H₁₁ClN₆O₂S₂
• Purity: 99.84%
• Color and Shape: Solid
• Molecular weight: 370.84

Azosemide

CAS: 27589-33-9

• Formula: C₁₂H₁₁ClN₆O₂S₂
• Molecular weight: 370.84

Azosemide

CAS: 27589-33-9

• Purity: ≥98%
• Molecular weight: 370.84g/mol

2-Chloro-5-(2H-Tetrazol-5-Yl)-4-((Thiophen-2-Ylmethyl)Amino)Benzenesulfonamide

CAS: 27589-33-9

• Purity: 97%
• Molecular weight: 370.84g/mol

Azosemide

CAS: 27589-33-9

• Formula: C₁₂H₁₁ClN₆O₂S₂
• Purity: >98.0%(T)(HPLC)
• Color and Shape: White to Light yellow powder to crystal
• Molecular weight: 370.83

Azosemide

CAS: 27589-33-9

Applications Azosemide is a high-ceiling diuretic agent. It is used in the treatment of edematous …

• Formula: C₁₂H₁₁ClN₆O₂S₂
• Color and Shape: Neat
• Molecular weight: 370.84

2-Chloro-5-(2H-tetrazol-5-yl)-4-((thiophen-2-ylmethyl)amino)benzenesulfonamide

CAS: 27589-33-9

• Purity: 97.0%
• Color and Shape: Liquid
• Molecular weight: 370.8299865722656

Azosemide

CAS: 27589-33-9

Please enquire for more information about Azosemide including the price, delivery time and more detailed …

• Formula: C₁₂H₁₁ClN₆O₂S₂
• Purity: Min. 95%
• Color and Shape: White Powder
• Molecular weight: 370.84 g/mol