CAS 27589-33-9

Azosemide

Description:

Azosemide is a chemical compound classified as a loop diuretic, primarily used in the treatment of conditions such as edema associated with heart failure and hypertension. It functions by inhibiting the sodium-potassium-chloride co-transporter in the thick ascending limb of the loop of Henle in the kidneys, leading to increased excretion of sodium, chloride, and water. This mechanism results in diuresis, helping to reduce fluid overload in patients. Azosemide is characterized by its relatively high solubility in water, which facilitates its administration and absorption in the body. The compound has a specific chemical structure that contributes to its pharmacological activity, and it is often administered orally or intravenously, depending on the clinical scenario. As with other diuretics, potential side effects may include electrolyte imbalances, dehydration, and renal function impairment, necessitating careful monitoring during treatment. Overall, azosemide is an important therapeutic agent in managing fluid retention and hypertension, particularly in patients with cardiovascular conditions.

Formula: C₁₂H₁₁ClN₆O₂S₂

InChI: InChI=1S/C12H11ClN6O2S2/c13-9-5-10(15-6-7-2-1-3-22-7)8(12-16-18-19-17-12)4-11(9)23(14,20)21/h1-5,15H,6H2,(H2,14,20,21)(H,16,17,18,19)

InChI key: InChIKey=HMEDEBAJARCKCT-UHFFFAOYSA-N

SMILES: N(CC1=CC=CS1)C2=C(C=C(S(N)(=O)=O)C(Cl)=C2)C=3NN=NN3

Synonyms:

• 2-Chloro-5-(1H-tetrazol-5-yl)-4-[(2-thienylmethyl)amino]benzenesulfonamide
• 2-Chloro-5-(2H-tetrazol-5-yl)-4-(thiophen-2-ylmethylamino)benzenesulfonamide
• 2-Chloro-5-(2H-tetrazol-5-yl)-4-[(2-thienylmethyl)amino]benzenesulfonamide
• 2-Chloro-5-(2H-tetrazol-5-yl)-N4-2-thenylsulfanilamide
• 2-chloro-5-(1H-tetrazol-5-yl)-4-[(thiophen-2-ylmethyl)amino]benzenesulfonamide
• 2-chloro-5-(2H-tetrazol-5-yl)-4-[(thiophen-2-ylmethyl)amino]benzenesulfonamide
• 248-549-7
• 5-(4'-Chloro-2'-thenylamino-5'-sulfamoylphenyl)tetrazole
• 5-(4-Chloro-5-sulfamoyl-2-thenylaminophenyl)tetrazole
• Benzenesulfonamide, 2-chloro-5-(2H-tetrazol-5-yl)-4-[(2-thienylmethyl)amino]-
• Diart
• Diurapid
• Luret
• Ple 1053
• SK 110 (pharmaceutical)
• Sk 110
• Sulfanilamide, 2-chloro-5-(1H-tetrazol-5-yl)-N⁴-2-thenyl-
• benzenesulfonamide, 2-chloro-5-(1H-tetrazol-5-yl)-4-[(2-thienylmethyl)amino]-

Benzenesulfonamide, 2-chloro-5-(2H-tetrazol-5-yl)-4-[(2-thienylmethyl)amino]-

CAS: 27589-33-9

Formula: C₁₂H₁₁ClN₆O₂S₂

Purity: 97%

Color and Shape: Solid

Molecular weight: 370.8377

Ref: IN-DA002U6L

Azosemide

CAS: 27589-33-9

Azosemide is a potent NKCC1 inhibitor (IC50s: 0.246 µM and 0.197 µM for hNKCC1A and NKCC1B).

Formula: C₁₂H₁₁ClN₆O₂S₂

Purity: 99.84%

Color and Shape: Solid

Molecular weight: 370.84

Ref: TM-T10441

Azosemide

CAS: 27589-33-9

Formula: C₁₂H₁₁ClN₆O₂S₂

Molecular weight: 370.84

Ref: 7W-GP0304

Azosemide

CAS: 27589-33-9

Azosemide

Purity: ≥98%

Molecular weight: 370.84g/mol

Ref: 54-BUP11815

2-Chloro-5-(2H-Tetrazol-5-Yl)-4-((Thiophen-2-Ylmethyl)Amino)Benzenesulfonamide

CAS: 27589-33-9

2-Chloro-5-(2H-Tetrazol-5-Yl)-4-((Thiophen-2-Ylmethyl)Amino)Benzenesulfonamide

Purity: 97%

Molecular weight: 370.84g/mol

Ref: 54-OR1027687

Azosemide

CAS: 27589-33-9

Formula: C₁₂H₁₁ClN₆O₂S₂

Purity: >98.0%(T)(HPLC)

Color and Shape: White to Light yellow powder to crystal

Molecular weight: 370.83

Ref: 3B-A3544

Azosemide

Controlled Product

CAS: 27589-33-9

Applications Azosemide is a high-ceiling diuretic agent. It is used in the treatment of edematous states and hypertension.
References Ogawa, K., et al.: Inter. J. Clin. Pharm. Ther. Toxicol., 22, 401 (1984); Suh, O., et al.: Biopharm. Drug Disposition., 24, 275 (2003)

Formula: C₁₂H₁₁ClN₆O₂S₂

Color and Shape: Neat

Molecular weight: 370.84

Ref: TR-A965145

2-Chloro-5-(2H-tetrazol-5-yl)-4-((thiophen-2-ylmethyl)amino)benzenesulfonamide

CAS: 27589-33-9

Purity: 97.0%

Color and Shape: Liquid

Molecular weight: 370.8299865722656

Ref: 10-F540940

Azosemide

CAS: 27589-33-9

Azosemide is a diuretic drug that increases the excretion of water and electrolytes. It is used in the treatment of congestive heart failure, high blood pressure, and certain kidney diseases. Azosemide is a non-steroidal anti-inflammatory drug that inhibits prostaglandin synthesis. It has been shown to have cardiac effects by increasing the incidence of ventricular arrhythmias in animals and humans when given intravenously. The pharmacodynamics and pharmacological properties of azosemide are not well understood, but it has been shown to be an effective treatment for congestive heart failure.

Formula: C₁₂H₁₁ClN₆O₂S₂

Purity: Min. 95%

Color and Shape: White Powder

Molecular weight: 370.84 g/mol

Ref: 3D-FA44032