CAS 27607-77-8

Trimethylsilyl triflate

Description:

Trimethylsilyl triflate, with the CAS number 27607-77-8, is a chemical compound that serves as a powerful silylating agent and a reagent in organic synthesis. It is characterized by its triflate group, which enhances its reactivity, making it useful in various chemical transformations, particularly in the protection of alcohols and amines. The compound is typically a colorless to pale yellow liquid with a pungent odor and is known for its high volatility. Trimethylsilyl triflate is soluble in organic solvents such as dichloromethane and acetonitrile but is less soluble in water. It is highly reactive and can hydrolyze in the presence of moisture, releasing triflic acid, which is a strong acid. Due to its reactivity, it must be handled with care, using appropriate safety measures to avoid skin and eye contact, as well as inhalation of vapors. Its applications extend to areas such as polymer chemistry, where it can facilitate the synthesis of complex molecules and materials.

Formula: C₄H₉F₃O₃SSi

InChI: InChI=1/C18H3F35O6/c19-2(1-54,8(26,27)28)55-15(46,47)4(22,10(32,33)34)57-17(50,51)6(24,12(38,39)40)59-18(52,53)7(25,13(41,42)43)58-16(48,49)5(23,11(35,36)37)56-14(44,45)3(20,21)9(29,30)31/h54H,1H2

InChI key: InChIKey=FTVLMFQEYACZNP-UHFFFAOYSA-N

SMILES: S(O[Si](C)(C)C)(C(F)(F)F)(=O)=O

Synonyms:

• Methanesulfonate, Trimethylsilyl Trifluoro-
• Methanesulfonic acid, 1,1,1-trifluoro-, trimethylsilyl ester
• Silanol, trimethyl-, trifluoromethanesulfonate
• TMSOTf
• Trifluorometanosulfonato De Trimetilsililo
• Trifluoromethanesulfonate de trimethylsilyle
• Trifluoromethanesulfonic acid trimethylsilyl ester
• Trimethylsilanol trifluoromethanesulfonate
• Trimethylsilyl Trifluoromethanesulphonate
• Trimethylsilyl trfluoromethanesulfonate
• Trimethylsilyl triflate
• Trimethylsilyl trifluoromethanesulfonate
• Trimethylsilyl trifluoromethylsulfonate
• Trimethylsilyltrifluormethansulfonat
• Trimethylsilyl trifluoromethylsulphonate
• Methanesulfonic acid, trifluoro-, trimethylsilyl ester
• Trimethylsilyltrifluoromethanesulfonate
• trimethyl-(trifluoromethylsulfonyloxy)silane
• trifluoro-methanesulfonicacitrimethylsilylester
• Methanesulfonicacid,trifluoro-,trimethylsilylester
• Trimethylsllytrifluoromethanesulphonate
• Trimethylsilyltrifluoromethanesulfonate,Anti-Tumor
• CT3795
• trimethylsilyl-trifluoromethansulfonate
• TRIMETHYLSILYL TRIFLUOROMETHANESULFONATE 99%
• Trifluormethansulfonicanhydrid
• TMS TRIFLATE
• SILANE TMS-TRIFLATE

Trimethylsilyl Trifluoromethanesulfonate

CAS: 27607-77-8

Formula: C₄H₉F₃O₃SSi

Purity: >98.0%(T)

Color and Shape: Colorless to Light yellow to Light orange clear liquid

Molecular weight: 222.25

Ref: 3B-T0871

Trimethylsilyl trifluoromethanesulfonate, 99%

CAS: 27607-77-8

Trimethylsilyl trifluoromethanesulfonate is used to prepare powerful Lewis acid, difluoroboron triflate etherate in acetonitrile solvent. It is also used as a reagent in a Dieckmann-like cyclization of ester-imides and diesters. Further, it is used in the conversion of carbonyl compounds to their en

Formula: C₄H₉F₃O₃SSi

Purity: 99%

Color and Shape: Clear, colorless to pale yellow or pale pink, Liquid

Molecular weight: 222.25

Ref: 02-A12535

Trimethylsilyl trifluoromethanesulfonate, min. 97%

CAS: 27607-77-8

Trimethylsilyl trifluoromethanesulfonate, min. 97%

Formula: CF₃SO₃Si(CH₃)₃

Purity: min. 97%

Color and Shape: colorless liq.

Molecular weight: 222.26

Ref: 08-14-8600

Trimethylsilyl trifluoromethanesulphonate

CAS: 27607-77-8

Trimethylsilyl trifluoromethanesulphonate

Formula: C₄H₉F₃O₃SSi

Purity: 98%

Color and Shape: clear. dark yellow to very dark yellow liquid

Molecular weight: 222.25816g/mol

Ref: 54-PC7867

Trimethylsilyl trifluoromethanesulphonate

CAS: 27607-77-8

S20400 - Trimethylsilyl trifluoromethanesulphonate

Formula: C₄H₉F₃O₃SSi

Purity: 98%

Color and Shape: Liquid, Clear

Molecular weight: 222.25

Ref: 10-S20400

Trifluoromethanesulfonic acid trimethylsilyl ester

CAS: 27607-77-8

Used in a Dieckmann-like cyclization of ester-imides and diesters

Formula: C₄H₉F₃O₃SSi

Purity: Titration Min. 98%

Color and Shape: Yellow Clear Liquid

Molecular weight: 222.26 g/mol

Ref: 3D-FT03406

TRIMETHYLSILYL TRIFLUOROMETHANESULFONATE CYLINDER

CAS: 27607-77-8

Trimethylsilyl Blocking Agent
Used as a protecting group for reactive hydrogens in alcohols, amines, thiols, and carboxylic acids. Organosilanes are hydrogen-like, can be introduced in high yield, and can be removed under selective conditions. They are stable over a wide range of reaction conditions and can be removed in the presence of other functional groups, including other protecting groups. The tolerance of silylated alcohols to chemical transformations summary is presented in Table 1 of the Silicon-Based Blocking Agents brochure.
Trimethylsilyltrifluoromethanesulfonate; Trimethylsilyltriflate; TMSOTf
Strong silylating agent for C- or O-silylationsReacts with nitroalkanes to give N,N-bis(trimethylsiloxy)enaminesNafion SAC-13 has been shown to be a recyclable catalyst for the trimethylsilylation of primary, secondary, and tertiary alcohols in excellent yields and short reaction timesSummary of selective deprotection conditions is provided in Table 7 through Table 20 of the Silicon-Based Blocking Agents brochure

Formula: C₄H₉F₃O₃SSi

Color and Shape: Straw Liquid

Molecular weight: 222.25

Ref: 3H-SIT8620.0

Trimethylsilyl trifluoromethane sulfonate

CAS: 27607-77-8

Trimethylsilyl trifluoromethane sulfonate (TMSOTf) is a versatile building block for the synthesis of complex organic compounds. It is a reagent and an intermediate for the production of other fine chemicals and speciality chemicals. TMSOTf is mainly used as a catalyst in organic reactions, such as the Suzuki-Miyaura reaction. TMSOTf can be used to synthesize pharmaceuticals, agrochemicals, and other important chemical products. This compound has been shown to be useful in the construction of synthetic scaffolds that are found in many drug molecules.

Formula: C₄H₉F₃O₃SSi

Molecular weight: 222.26 g/mol

Ref: 3D-T-6700