CAS 2765060-22-6

Triantennary GalNAc DBCO #1

Synonyms:

• Triantennary GalNAc DBCO #1

Trivalent GalNAc-DBCO

CAS: 2765060-22-6

Trivalent GalNAc-DBCO is a synthetic ligand composed of three GalNAc units linked to DBCO. Trivalent GalNAc-DBCO undergoes strain-promoted alkyne–azide cycloaddition (SPAAC) reactions with azide-containing molecules without the need for copper catalysis. Trivalent GalNAc-DBCO binds specifically to the asialoglycoprotein receptor (ASGPR), thereby directing conjugated molecules into hepatocytes for lysosomal degradation through receptor-mediated endocytosis. Trivalent GalNAc-DBCO is extensively applied in studies of liver-targeted drug delivery, targeted degradation strategies, and hepatocyte-specific molecular engineering.

Formula: C₉₁H₁₄₄N₁₂O₃₄

Purity: 96.33%

Molecular weight: 1950.18

Ref: TM-T210528