CAS 27652-34-2

Thio-ITP

Description:

Thio-ITP, or thio-inosine triphosphate, is a nucleotide analog characterized by the presence of a sulfur atom in its structure, which differentiates it from its natural counterpart, inosine triphosphate (ITP). This compound is known for its role in biochemical research, particularly in studies involving RNA and protein synthesis. Thio-ITP can participate in various enzymatic reactions and is often utilized as a substrate in experiments to investigate the mechanisms of RNA polymerases and other nucleic acid-related enzymes. Its unique properties allow it to mimic the behavior of natural nucleotides while providing insights into the dynamics of nucleic acid interactions. Additionally, Thio-ITP can influence the stability and structure of RNA, making it a valuable tool in molecular biology. The compound is typically handled with standard laboratory safety precautions, as with other nucleotides, and is stored under conditions that prevent degradation. Overall, Thio-ITP serves as an important reagent in the field of biochemistry and molecular biology, facilitating advancements in our understanding of nucleic acid functions.

Formula: C₁₀H₁₅N₄O₁₃P₃S

InChI: InChI=1S/C10H15N4O13P3S/c15-6-4(1-24-29(20,21)27-30(22,23)26-28(17,18)19)25-10(7(6)16)14-3-13-5-8(14)11-2-12-9(5)31/h2-4,6-7,10,15-16H,1H2,(H,20,21)(H,22,23)(H,11,12,31)(H2,17,18,19)/t4-,6-,7-,10-/m1/s1

InChI key: InChIKey=GQNRDWAOABGWGP-KQYNXXCUSA-N

SMILES: O[C@H]1[C@H](N2C3=C(N=C2)C(=S)N=CN3)O[C@H](COP(OP(OP(=O)(O)O)(=O)O)(=O)O)[C@H]1O

Synonyms:

• 9H-Purine-6-thiol, 9-β-D-ribofuranosyl-, 5′-triphosphate
• 9H-Purine-6(1H)-thione, 9-β-D-ribofuranosyl-, 5′-(tetrahydrogen triphosphate)
• 6-Thioinosine 5′-(tetrahydrogen triphosphate)
• Inosine 5′-(tetrahydrogen triphosphate), 6-thio-
• 6-Mercapto-9-β-D-ribofuranosylpurine 5′-triphosphate

Thio-ITP

CAS: 27652-34-2

Thio-ITP (6-Thioinosine 5'-triphosphate) inhibits RNA polymerases I & II with Ki of 40.9 & 38.0 μM.

Formula: C₁₀H₁₅N₄O₁₃P₃S

Color and Shape: Solid

Molecular weight: 524.23

Ref: TM-T40359

6-Thioinosine 5'-Triphosphate

Controlled Product

CAS: 27652-34-2

Formula: C₁₀H₁₅N₄O₁₃P₃S

Color and Shape: Neat

Molecular weight: 524.231

Ref: TR-T448210