CAS 27653-67-4

Trimethoprim 3-oxide

Description:

Trimethoprim 3-oxide, with the CAS number 27653-67-4, is a derivative of trimethoprim, a widely used antibiotic that inhibits bacterial dihydrofolate reductase. This compound is characterized by its structural modifications that enhance its pharmacological properties. Trimethoprim 3-oxide is typically a white to off-white crystalline solid, exhibiting moderate solubility in water and organic solvents. It possesses a molecular formula that reflects its nitrogen and oxygen content, which contributes to its biological activity. The compound is primarily studied for its potential antimicrobial effects and is often evaluated in the context of resistance mechanisms in bacteria. Its stability and reactivity can vary based on environmental conditions, making it important for researchers to consider these factors during experimentation. Additionally, the compound's safety profile and toxicity are essential for its application in clinical settings, necessitating thorough investigation in pharmacological studies. Overall, Trimethoprim 3-oxide represents a significant area of interest in medicinal chemistry and microbiology.

Formula: C₁₄H₁₈N₄O₄

InChI: InChI=1S/C14H18N4O4/c1-20-10-5-8(6-11(21-2)12(10)22-3)4-9-7-17-14(16)18(19)13(9)15/h5-7H,4,15H2,1-3H3,(H2,16,17)

InChI key: InChIKey=WDZLEQOJJCXUSW-UHFFFAOYSA-N

SMILES: O(C)C1=C(OC)C=C(CC=2C(N)=N(=O)C(N)=NC2)C=C1OC

Synonyms:

• Pyrimidine, 2,4-diamino-5-(3,4,5-trimethoxybenzyl)-, 3-oxide
• Trimethoprim 3-N-oxide
• Trimethoprim 3-oxide
• 2,4-Diamino-5-(3,4,5-trimethoxybenzyl)pyrimidine 3-oxide
• 2,4-Pyrimidinediamine, 5-[(3,4,5-trimethoxyphenyl)methyl]-, 3-oxide

2,4-Pyrimidinediamine, 5-[(3,4,5-trimethoxyphenyl)methyl]-, 3-oxide

CAS: 27653-67-4

Formula: C₁₄H₁₈N₄O₄

Color and Shape: Solid

Molecular weight: 306.3171

Ref: IN-DA002UCH

Trimethoprim Impurity 6

CAS: 27653-67-4

Formula: C₁₄H₁₈N₄O₄

Molecular weight: 306.32

Ref: 4Z-T-7018

(4-Trideuteromethoxy) Trimethoprim N3-Oxide

Controlled Product

CAS: 27653-67-4

Formula: C₁₄D₃H₁₅N₄O₄

Color and Shape: Neat

Molecular weight: 309.336

Ref: TR-T797547

Trimethoprim 3-N-Oxide

Controlled Product

CAS: 27653-67-4

Formula: C₁₄H₁₈N₄O₄

Color and Shape: Neat

Molecular weight: 306.3171

Ref: TR-T797545

Trimethoprim 3-oxide

CAS: 27653-67-4

Trimethoprim 3-oxide trimethoprim primary metabolite.

Formula: C₁₄H₁₈N₄O₄

Purity: 98%

Color and Shape: Solid

Molecular weight: 306.32

Ref: TM-T19593

Trimethoprim 3-N-oxide

CAS: 27653-67-4

Trimethoprim 3-N-oxide is a metabolite of trimethoprim, which is used to treat urinary tract infections. It is excreted in the urine and its concentration can be measured by gas chromatography. Trimethoprim 3-N-oxide has been shown to inhibit bacterial growth in vitro and has been found to be effective against methicillin resistant Staphylococcus aureus (MRSA).

Formula: C₁₄H₁₈N₄O₄

Purity: Min. 95%

Molecular weight: 306.32 g/mol

Ref: 3D-CBA65367