CAS 27653-68-5

Trimethoprim 1-oxide

Description:

Trimethoprim 1-oxide, with the CAS number 27653-68-5, is a derivative of the antibiotic trimethoprim, which is primarily used to treat bacterial infections. This compound is characterized by its structural modification that includes the presence of an oxide functional group. Trimethoprim itself is a dihydrofolate reductase inhibitor, which disrupts folate synthesis in bacteria, thereby inhibiting their growth. The 1-oxide variant may exhibit altered pharmacological properties compared to its parent compound, potentially affecting its efficacy and safety profile. In terms of physical properties, trimethoprim 1-oxide is typically a solid at room temperature and may have specific solubility characteristics in various solvents. Its stability, reactivity, and interaction with biological systems can differ from trimethoprim, making it a subject of interest in pharmaceutical research. As with many chemical substances, safety data should be consulted to understand its handling and potential hazards. Overall, trimethoprim 1-oxide represents an important compound in the study of antibiotic mechanisms and drug development.

Formula: C₁₄H₁₈N₄O₄

InChI: InChI=1S/C14H18N4O4/c1-20-10-5-8(6-11(21-2)12(10)22-3)4-9-7-18(19)14(16)17-13(9)15/h5-7H,4H2,1-3H3,(H4,15,16,17)

InChI key: InChIKey=FOPGIVDHWKZJDQ-UHFFFAOYSA-N

SMILES: C(C1=CC(OC)=C(OC)C(OC)=C1)C=2C(N)=NC(N)=N(=O)C2

Synonyms:

• Trimethoprim 1-N-oxide
• Pyrimidine, 2,4-diamino-5-(3,4,5-trimethoxybenzyl)-, 1-oxide
• 2,4-Diamino-5-(3,4,5-trimethoxybenzyl)pyrimidine 1-oxide
• Trimethoprim 1-oxide
• 2,4-Pyrimidinediamine, 5-[(3,4,5-trimethoxyphenyl)methyl]-, 1-oxide
• Trimethoprim Impurity 5
• Trimethoprim N-oxide 1
• Trimethoprim N-oxide

Trimethoprim Impurity 5

CAS: 27653-68-5

Formula: C₁₄H₁₈N₄O₄

Molecular weight: 306.32

Ref: 4Z-T-7017

Trimethoprim 1-N-Oxide

Controlled Product

CAS: 27653-68-5

Formula: C₁₄H₁₈N₄O₄

Color and Shape: Neat

Molecular weight: 306.3171

Ref: TR-T797535

Trimethoprim N-oxide

CAS: 27653-68-5

Trimethoprim N-oxide is a human urinary metabolite.

Formula: C₁₄H₁₈N₄O₄

Purity: 98%

Color and Shape: Solid

Molecular weight: 306.32

Ref: TM-T19592

(4-Trideuteromethoxy) Trimethoprim N1-Oxide, ~90%

Controlled Product

CAS: 27653-68-5

Formula: C₁₄H₁₅D₃N₄O₄

Purity: ~90%

Color and Shape: Neat

Molecular weight: 309.34

Ref: TR-T797537

Trimethoprim N-oxide

CAS: 27653-68-5

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Formula: C₁₄H₁₈N₄O₄

Purity: Min. 95%

Molecular weight: 306.32 g/mol

Ref: 3D-CBA65368