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CAS 2768868-14-8

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  • KRASG12C IN-15
    Targetmol
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    KRASG12C IN-15

    CAS:
    <p>KRASG12C IN-15 (Compound 21) is an orally active KRASG12C inhibitor that effectively blocks SOS1-mediated GDP/GTP exchange with an IC50 of 19 nM. It inhibits ERK phosphorylation with an IC50 of 0.051 μM and reduces the viability of KRASG12C mutant MIA PaCa-2 cells with an IC50 of 0.023 μM. Additionally, KRASG12C IN-15 demonstrates antitumor activity in a MIA PaCa-2 xenograft mouse model.</p>
    Formula:C31H32FN3O2
    Color and Shape:Solid
    Molecular weight:497.603

    Ref: TM-T205541