CAS 27740-01-8

Scutellarin

Description:

Scutellarin is a flavonoid glycoside primarily derived from the plant Scutellaria baicalensis, commonly known as Baikal skullcap. It is characterized by its chemical structure, which includes a flavone backbone linked to a glucose moiety. Scutellarin exhibits various biological activities, including antioxidant, anti-inflammatory, and neuroprotective effects, making it of interest in pharmacological research. The compound is soluble in water and exhibits moderate stability under standard conditions. Its potential therapeutic applications are being explored in areas such as neurodegenerative diseases and cardiovascular health. Additionally, scutellarin has been studied for its ability to modulate various signaling pathways, contributing to its diverse pharmacological effects. As with many natural compounds, the efficacy and safety of scutellarin are subject to ongoing research, particularly regarding its bioavailability and mechanisms of action in biological systems.

Formula: C₂₁H₁₈O₁₂

InChI: InChI=1S/C21H18O12/c22-8-3-1-7(2-4-8)10-5-9(23)13-11(31-10)6-12(14(24)15(13)25)32-21-18(28)16(26)17(27)19(33-21)20(29)30/h1-6,16-19,21-22,24-28H,(H,29,30)/t16-,17-,18+,19-,21+/m0/s1

InChI key: InChIKey=DJSISFGPUUYILV-ZFORQUDYSA-N

SMILES: O=C1C=2C(OC(=C1)C3=CC=C(O)C=C3)=CC(O[C@@H]4O[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@H]4O)=C(O)C2O

Synonyms:

• 5,6-Dihydroxy-2-(4-hydroxyphenyl)-4-oxo-4H-1-benzopyran-7-yl β-<span class="text-smallcaps">D</span>-glucopyranosiduronic acid
• 7-(beta-D-Glucopyranuronosyloxy)-5,6-dihydroxy-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-one
• Flavone, 4′,5,6,7-tetrahydroxy-, 7-β-<span class="text-smallcaps">D</span>-glucopyranuronoside
• Glucopyranosiduronic acid, 5,6-dihydroxy-2-(p-hydroxyphenyl)-4-oxo-4H-1-benzopyran-7-yl, β-<span class="text-smallcaps">D</span>-
• Scutellarein 7-O-β-<span class="text-smallcaps">D</span>-glucuronide
• Scutellarein 7-O-β-glucuronide
• Scutellarein 7-glucuronide
• Scutellarein 7-β-<span class="text-smallcaps">D</span>-glucuronide
• Scutellarein 7-β-<span class="text-smallcaps">D</span>-glucuronoside
• Scutellarin B
• β-<span class="text-smallcaps">D</span>-Glucopyranosiduronic acid, 5,6-dihydroxy-2-(4-hydroxyphenyl)-4-oxo-4H-1-benzopyran-7-yl
• Glucopyranosiduronic acid, 5,6-dihydroxy-2-(p-hydroxyphenyl)-4-oxo-4H-1-benzopyran-7-yl, β-D-
• Flavone, 4′,5,6,7-tetrahydroxy-, 7-β-D-glucopyranuronoside
• β-D-Glucopyranosiduronic acid, 5,6-dihydroxy-2-(4-hydroxyphenyl)-4-oxo-4H-1-benzopyran-7-yl
• Scutellarin

Scutellarin

CAS: 27740-01-8

Scutellarin analytical standard provided with w/w absolute assay, to be used for quantitative titration.

Formula: C₂₁H₁₈O₁₂

Purity: (HPLC) ≥98%

Color and Shape: Powder

Molecular weight: 462.37

Ref: 11-1405S

β-D-Glucopyranosiduronic acid, 5,6-dihydroxy-2-(4-hydroxyphenyl)-4-oxo-4H-1-benzopyran-7-yl

CAS: 27740-01-8

Formula: C₂₁H₁₈O₁₂

Purity: 97%

Color and Shape: Solid

Molecular weight: 462.3604

Ref: IN-DA002UML

Scutellarin

CAS: 27740-01-8

Formula: C₂₁H₁₈O₁₂

Purity: (HPLC) ≥ 98.0%

Color and Shape: Yellow to brown powder

Molecular weight: 462.36

Ref: 7W-GC9987

(2S,3S,4S,5R,6S)-6-((5,6-Dihydroxy-2-(4-Hydroxyphenyl)-4-Oxo-4H-Chromen-7-Yl)Oxy)-3,4,5-Trihydroxytetrahydro-2H-Pyran-2-Carboxylic Acid

CAS: 27740-01-8

(2S,3S,4S,5R,6S)-6-((5,6-Dihydroxy-2-(4-Hydroxyphenyl)-4-Oxo-4H-Chromen-7-Yl)Oxy)-3,4,5-Trihydroxytetrahydro-2H-Pyran-2-Carboxylic Acid

Purity: 98%

Molecular weight: 462.36g/mol

Ref: 54-OR1008029

Scutellarin

CAS: 27740-01-8

Scutellarin

Purity: ≥95%

Molecular weight: 462.36g/mol

Ref: 54-BUP11189

Scutellarin

CAS: 27740-01-8

Scutellarin has many pharmacological effects, such as antioxidant, antitumor, antiviral, neuroprotection and antiinflammatory activities. It down-regulates the STAT3/Girdin/Akt signaling in HCC cells, and inhibits RANKL-mediated MAPK and NF-κB signaling pathway in osteoclasts.

Formula: C₂₁H₁₈O₁₂

Purity: 95%~99%

Molecular weight: 462.363

Ref: BP-BP1278

Scutellarin

CAS: 27740-01-8

Scutellarin from Scutellaria inhibits RANKL in osteoclasts and STAT3/Girdin/Akt in HCC cells.

Formula: C₂₁H₁₈O₁₂

Purity: 97.12% - 99.75%

Color and Shape: Solid

Molecular weight: 462.36

Ref: TM-T2789

Scutellarin

CAS: 27740-01-8

Natural glycoside

Formula: C₂₁H₁₈O₁₂

Purity: ≥ 95.0 % (HPLC)

Color and Shape: Powder

Molecular weight: 462.37

Ref: 5G-89788

Scutellarin

CAS: 27740-01-8

Applications Scutellarin is an active flavonoid component from the medical plant Erigeron breviscapus (Vant) Hand-Mazz. Scutellarin is used as a micrpcirculation promoter for the treatment of cardio-cerebrovascular diseases. Studies suggest that Scutellarin has anti-cancer properties and has been shown to enhance apoptosis of tumor cells.
References Gao, C. et al.: Drug Metab. Dispos., 39, 2034 (2011); Chan, J.Y. et al.: Anticancer Res., 29, 3043 (2009); Wang, C.-Z. et al.: Phytomedicine, 17, 63 (2010);

Formula: C₂₁H₁₈O₁₂

Color and Shape: Neat

Molecular weight: 462.36

Ref: TR-S201900

Scutellarin

CAS: 27740-01-8

Scutellarin is a bioactive flavonoid compound, which is derived primarily from the plant Scutellaria baicalensis and other species within the Scutellaria genus. As a naturally occurring phytochemical, Scutellarin exerts its effects through multiple biological pathways, including antioxidant, anti-inflammatory, and anti-apoptotic activities.

Formula: C₂₁H₁₈O₁₂

Purity: Min. 95%

Color and Shape: Yellow Powder

Molecular weight: 462.36 g/mol

Ref: 3D-MS08111