CAS 2776965-41-2

Glucosylceramide synthase-IN-4

Description:

Glucosylceramide synthase-IN-4, identified by its CAS number 2776965-41-2, is a chemical compound that serves as an inhibitor of the enzyme glucosylceramide synthase. This enzyme is crucial in the biosynthesis of glucosylceramide, a glycosphingolipid involved in various cellular processes, including cell signaling and membrane structure. The inhibition of glucosylceramide synthase has potential therapeutic implications, particularly in the treatment of lysosomal storage disorders, such as Gaucher disease, where glucosylceramide accumulates due to enzyme deficiencies. The compound's structure typically features specific functional groups that allow it to interact effectively with the enzyme's active site, thereby blocking its activity. In terms of pharmacological properties, glucosylceramide synthase-IN-4 may exhibit characteristics such as selectivity, potency, and favorable bioavailability, which are essential for its efficacy as a therapeutic agent. Further studies are often conducted to evaluate its safety profile, pharmacokinetics, and potential side effects in biological systems.

Synonyms:

• Glucosylceramide synthase-IN-4

Glucosylceramide synthase-IN-4

CAS: 2776965-41-2

Glucosylceramide Synthase-IN-4 (compound 12) serves as a potent inhibitor of glucosylceramide synthase (GCS), exhibiting an IC50 of 6.8 nM. It demonstrates superior pharmacokinetic properties and robust stability in human hepatocytes. Additionally, this compound is noted for its effective CNS penetration and acceptable PXR selectivity [1].

Formula: C₂₂H₁₈F₅N₃O₃

Color and Shape: Solid

Molecular weight: 467.39

Ref: TM-T86511