CAS 2782022-40-4

LD4172

CAS: 2782022-40-4

LD4172 is a PROTAC degrader capable of degrading RIP kinase (RIPK1) with a DC50 in the nanomolar range. When used in combination with TNF-α, LD4172 can induce apoptosis in B16F10 cells. In mouse models, it demonstrates antitumor activity. (Pink: ligand for target protein; Black: linker; Blue: ligand for E3 ligase VHL)

Formula: C₆₁H₇₅F₃N₁₀O₇S

Color and Shape: Solid

Molecular weight: 1149.37

Ref: TM-T204416