CAS 27877-51-6

Tolindate

Description:

Tolindate, with the CAS number 27877-51-6, is a chemical compound primarily recognized for its use as a pharmaceutical agent. It is classified as a non-steroidal anti-inflammatory drug (NSAID) and is known for its analgesic and anti-inflammatory properties. The compound typically appears as a white to off-white crystalline powder, which is soluble in organic solvents but has limited solubility in water. Tolindate functions by inhibiting the cyclooxygenase (COX) enzymes, which play a crucial role in the biosynthesis of prostaglandins, thereby reducing inflammation and pain. Its pharmacokinetics involve absorption after oral administration, with a metabolism that may involve hepatic pathways. While it has therapeutic applications, like all medications, tolindate may also present side effects, including gastrointestinal disturbances and potential cardiovascular risks. As with any pharmaceutical, its use should be guided by a healthcare professional to ensure safety and efficacy.

Formula: C₁₈H₁₉NOS

InChI: InChI=1S/C18H19NOS/c1-13-5-3-8-16(11-13)19(2)18(21)20-17-10-9-14-6-4-7-15(14)12-17/h3,5,8-12H,4,6-7H2,1-2H3

InChI key: InChIKey=ANJNOJFLVNXCHT-UHFFFAOYSA-N

SMILES: O(C(N(C)C1=CC(C)=CC=C1)=S)C=2C=C3C(=CC2)CCC3

Synonyms:

• Carbamothioic acid, methyl(3-methylphenyl)-, O-(2,3-dihydro-1H-inden-5-yl) ester
• Methyl (3-Methylphenyl)carbamothioic Acid O-(2,3-Dihydro-1H-inden-5-yl) Ester
• 5-Indanol, m,N-dimethylthiocarbanilate
• Carbamothioic acid, N-methyl-N-(3-methylphenyl)-, O-(2,3-dihydro-1H-inden-5-yl) ester
• TOLINDATE
• Tolindate
• 27877-51-6
• O-(5-Indanyl) m,N-Dimethylthiocarbanilate
• O-(2,3-dihydro-1H-inden-5-yl) methyl(3-methylphenyl)carbamothioate
• Carbanilic acid, m,N-dimethylthio-, O-5-indanyl ester

Tolindate

CAS: 27877-51-6

Tolindate, a potent PXR agonist, demonstrates antifungal activity and possesses an EC50 value of 8.3 µM.

Formula: C₁₈H₁₉NOS

Color and Shape: Solid

Molecular weight: 297.41

Ref: TM-T73265