NSD2-PWWP1-IN-2, identified by its CAS number 2797183-32-3, is a small molecule inhibitor that targets the NSD2 (Nuclear Receptor Binding SET Domain Protein 2) protein, which is involved in histone methylation and plays a significant role in gene regulation and chromatin remodeling. This compound is part of a class of inhibitors designed to interfere with the PWWP domain of NSD2, potentially impacting its function in various biological processes, including cancer progression and development. The characteristics of NSD2-PWWP1-IN-2 include its molecular structure, which typically features specific functional groups that enhance its binding affinity to the target protein. Additionally, it may exhibit properties such as solubility in organic solvents, stability under physiological conditions, and a defined mechanism of action that involves modulation of histone methylation patterns. Research into this compound is ongoing, focusing on its therapeutic potential and efficacy in preclinical models, particularly in the context of hematological malignancies and other diseases associated with dysregulated histone modifications.

NSD2-PWWP1-IN-2

2797183-32-3: NSD2-PWWP1-IN-2, identified by its CAS number 2797183-32-3, is a small molecule inhibitor that targets the NSD2 (Nuclear Receptor Binding SET Domain Protein 2) protein, which is involved in histone methylation and plays a significant role in gene regulation and chromatin remodeling. This compound is part of a class of inhibitors designed to interfere with the PWWP domain of NSD2, potentially impacting its function in various biological processes, including cancer progression and development. The characteristics of NSD2-PWWP1-IN-2 include its molecular structure, which typically features specific functional groups that enhance its binding affinity to the target protein. Additionally, it may exhibit properties such as solubility in organic solvents, stability under physiological conditions, and a defined mechanism of action that involves modulation of histone methylation patterns. Research into this compound is ongoing, focusing on its therapeutic potential and efficacy in preclinical models, particularly in the context of hematological malignancies and other diseases associated with dysregulated histone modifications.

<p>NSD2-PWWP1-IN-2 (compound 33) is a potent NSD2-PWWP1 inhibitor, exhibiting an IC50 value of 1.49 µM, indicating its potential utility in cancer research.</p>

CAS 2797183-32-3

NSD2-PWWP1-IN-2

NSD2-PWWP1-IN-2

Ref: TM-T204831