CAS 27999-47-9

Uridine, 2'-deoxy-,5'-(4-methylbenzenesulfonate) (9CI)

Description:

Uridine, 2'-deoxy-, 5'-(4-methylbenzenesulfonate) is a chemical compound that belongs to the class of nucleosides, specifically a derivative of deoxyuridine. It features a uracil base linked to a deoxyribose sugar, with a sulfonate group attached to the 5' position of the sugar, which enhances its solubility and reactivity. The presence of the 4-methylbenzenesulfonate moiety contributes to its unique properties, making it useful in various biochemical applications, including as a building block in nucleic acid synthesis and in studies of RNA and DNA interactions. This compound is typically characterized by its molecular structure, which includes a pyrimidine ring, a deoxyribose sugar, and a sulfonate group, influencing its biological activity and potential therapeutic uses. Additionally, it may exhibit specific solubility characteristics in different solvents, which can be important for its application in laboratory settings. As with many nucleoside derivatives, it may also play a role in cellular processes and has potential implications in medicinal chemistry and drug development.

Formula: C₁₆H₁₈N₂O₇S

Synonyms:

• Uridine,2'-deoxy-, 5'-p-toluenesulfonate (8CI)
• 1-(5-O-Tosyl-2-deoxy-b-D-erythro-pentofuranosyl)uracil
• 2'-Deoxy-5'-O-p-toluenesulfonyluridine
• 5'-O-Tosyl-2'-deoxyuridine
• 5'-O-p-Tolylsulfonyl-2'-deoxyuridine

2''-Deoxy-5''-O-p-toluenesulfonyluridine

CAS: 27999-47-9

Ref: 7W-GN5994

5'-O-(p-Toluenesulfonyl)-2'-deoxyuridine

Controlled Product

CAS: 27999-47-9

Applications 5'-O-(p-Toluenesulfonyl)-2'-deoxyuridine can be used in biological study of exploring structural requirements for class of nucleoside inhibitors (PfdUTPase) as antimalarials using QSAR, pharmacophore mapping and multiple docking studies.
References Ojha, P. K., et al.: Comb Chem High T Scr, 16, 739 (2013)

Formula: C₁₆H₁₈N₂O₇S

Color and Shape: Neat

Molecular weight: 382.39

Ref: TR-T535948

2'-Deoxy-5'-O-p-toluenesulfonyluridine

CAS: 27999-47-9

2'-Deoxy-5'-O-p-toluenesulfonyluridine is a nucleoside that is modified with a p-toluenesulfonyl group on the 2' position. This compound has been shown to be an activator of phosphoramidites. It is also used as an anticancer drug, antiviral agent, and in the synthesis of ribonucleosides and deoxyribonucleosides. 2'-Deoxy-5'-O-p-toluenesulfonyluridine is typically used as a building block for RNA or DNA synthesis. This compound can also be used in the preparation of aminoglycoside antibiotics, as well as for the treatment of cancerous tumors.

Formula: C₁₆H₁₈N₂O₇S

Purity: Min. 95%

Molecular weight: 382.4 g/mol

Ref: 3D-ND06470