CAS 28094-15-7

6-Hydroxydopamine hydrochloride

Description:

6-Hydroxydopamine hydrochloride is a synthetic organic compound primarily used in neuroscience research, particularly for studying neurodegenerative diseases and the mechanisms of neuronal damage. It is a derivative of dopamine, characterized by the presence of a hydroxyl group at the 6-position of the aromatic ring. This compound is known for its neurotoxic properties, selectively damaging dopaminergic neurons, which makes it valuable for creating animal models of Parkinson's disease. In its hydrochloride form, it is a white to off-white crystalline powder that is soluble in water, facilitating its use in biological experiments. The compound is typically handled with caution due to its toxic effects on cells and potential environmental hazards. Additionally, it is important to note that 6-hydroxydopamine can induce oxidative stress and is often used in studies investigating the role of oxidative damage in neuronal cell death. Proper safety protocols should be followed when working with this substance in laboratory settings.

Formula: C₈H₁₁NO₃·ClH

InChI: InChI=1S/C8H11NO3.ClH/c9-2-1-5-3-7(11)8(12)4-6(5)10;/h3-4,10-12H,1-2,9H2;1H

InChI key: InChIKey=QLMRJHFAGVFUAC-UHFFFAOYSA-N

SMILES: C(CN)C1=C(O)C=C(O)C(O)=C1.Cl

Synonyms:

• 1,2,3-Benzenetriol, 4-(2-aminoethyl)-, hydrochloride
• 1,2,4-Benzenetriol, 5-(2-aminoethyl)-, hydrochloride
• 1,2,4-Benzenetriol, 5-(2-aminoethyl)-, hydrochloride (1:1)
• 2,4,5-Trihydroxyphenethylamine hydrochloride
• 4-(2-Aminoethyl)-1,2,3-benzenetriol hydrochloride
• 5-(2-Aminoethyl)-1,2,4-benzenetriol hydrochloride
• 5-(2-Aminoethyl)Benzene-1,2,4-Triol Hydrochloride (1:1)
• 6-Hydroxydopamine chloride
• 6-Hydroxydopamine hydrochloride
• Nsc 233898
• Oxidopamine HCl
• Oxidopamine hydrochloride

Oxidopamine (hydrochloride)

CAS: 28094-15-7

Formula: C₈H₁₂ClNO₃

Purity: 95%

Color and Shape: Solid

Molecular weight: 205.6388

Ref: IN-DA00BC03

Oxidopamine hydrochloride

CAS: 28094-15-7

Oxidopamine hydrochloride (6-Hydroxydopamine hydrochloride) is an neurotransmitter dopamine antagonist.

Formula: C₈H₁₂ClNO₃

Purity: 98.34% - 99.85%

Color and Shape: Physical Description Beige Solid (Ntp 1992)

Molecular weight: 205.64

Ref: TM-T12352

Oxidopamine hydrochloride

CAS: 28094-15-7

Oxidopamine hydrochloride

Purity: ≥95%

Molecular weight: 205.64g/mol

Ref: 54-BUP06632

6-Hydroxydopaminehydrochloride

CAS: 28094-15-7

6-Hydroxydopaminehydrochloride

Purity: 95%

Molecular weight: 205.64g/mol

Ref: 54-OR1025772

6-Hydroxydopamine hydrochloride

CAS: 28094-15-7

Formula: (HO)₃C₆H₂CH₂CH₂NH₂·HCl

Purity: ≥ 97.0%

Color and Shape: Off-white to brown powder

Molecular weight: 205.64

Ref: 7W-GL9003

5-(2-Aminoethyl)benzene-1,2,4-triol hydrochloride

CAS: 28094-15-7

5-(2-Aminoethyl)benzene-1,2,4-triol hydrochloride (MPP+) is a neurotoxin that inhibits the synthesis of dopamine and other neurotransmitters in dopaminergic neurons. MPP+ is generated by the oxidation of l-dopa, an amino acid precursor of the neurotransmitter dopamine. MPP+ causes oxidative injury to dopaminergic neurons by affecting their mitochondria. The inhibition of mitochondrial function leads to neuronal death and Parkinson's disease. MPP+ has been shown to be cytotoxic for pluripotent cells, such as embryonic stem cells, which are important for regenerative medicine. In addition, MPP+ has been shown to cause lesions in the brain and induce cell death in a model system using rat striatum neurons and astrocytes. This agent also inhibits polymerase chain reaction (PCR), which can be used as a diagnostic tool for Parkinson's disease.

Formula: C₈H₁₂ClNO₃

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 205.64 g/mol

Ref: 3D-DBA09415

Oxidopamine hydrochloride

CAS: 28094-15-7

Formula: C₈H₁₂ClNO₃

Purity: 97%

Molecular weight: 205.051

Ref: 10-F242528

6-Hydroxydopamine Hydrochloride

CAS: 28094-15-7

Formula: C₈H₁₁NO₃HCl

Molecular weight: 169.18 : 36.46

Ref: ST-EA-CP-D55020