CAS 28097-03-2

(+)-Chaetocin

Description:

(+)-Chaetocin is a naturally occurring compound classified as a polyketide, primarily derived from certain fungi, particularly those in the Chaetomium genus. It is known for its distinctive structural features, including a fused bicyclic ring system and multiple functional groups that contribute to its biological activity. This compound exhibits notable pharmacological properties, including potential anti-cancer and anti-inflammatory effects, making it a subject of interest in medicinal chemistry and drug development. (+)-Chaetocin has been shown to inhibit histone methyltransferases, which play a crucial role in epigenetic regulation, thereby influencing gene expression. Its mechanism of action and efficacy in various biological systems are areas of ongoing research. Additionally, (+)-Chaetocin's solubility and stability can vary depending on the solvent and environmental conditions, which are important considerations for its application in laboratory and therapeutic settings. Overall, (+)-Chaetocin represents a significant compound in the study of natural products and their potential therapeutic uses.

Formula: C₃₀H₂₈N₆O₆S₄

InChI: InChI=1/C30H28N6O6S4/c1-33-21(39)27-11-25(15-7-3-5-9-17(15)31-19(25)35(27)23(41)29(33,13-37)45-43-27)26-12-28-22(40)34(2)30(14-38,46-44-28)24(42)36(28)20(26)32-18-10-6-4-8-16(18)26/h3-10,19-20,31-32,37-38H,11-14H2,1-2H3

InChI key: InChIKey=PZPPOCZWRGNKIR-PNVYSBBASA-N

SMILES: O=C1N2[C@@]3([C@@](C=4C(N3)=CC=CC4)(C[C@]25C(=O)N(C)[C@@]1(CO)SS5)[C@@]67[C@@](N8[C@]9(C6)C(=O)N(C)[C@](CO)(C8=O)SS9)(NC=%10C7=CC=CC%10)[H])[H]

Synonyms:

• (+)-Chaetocin A
• (3S,3′S,5aR,5′aR,10bR,10′bR,11aS,11′aS)-2,2′,3,3′,5a,5′a,6,6′-Octahydro-3,3′-bis(hydroxymethyl)-2,2′-dimethyl[10b,10′b(11H,11′H)-bi-3,11a-epidithio-11aH-pyrazino[1′,2′:1,5]pyrrolo[2,3-b]indole]-1,1′,4,4′-tetrone
• 3,11a-Epidithio-11aH-pyrazino[1′,2′:1,5]pyrrolo[2,3-b]indole, bimol. deriv.
• Brn 5722505
• Chaetocin
• Chetocin
• [10b,10′b(11H,11′H)-Bi-3,11a-epidithio-11aH-pyrazino[1′,2′:1,5]pyrrolo[2,3-b]indole]-1,1′,4,4′-tetrone, 2,2′,3,3′,5a,5′a,6,6′-octahydro-3,3′-bis(hydroxymethyl)-2,2′-dimethyl-, (3S,3′S,5aR,5′aR,10bR,10′bR,11aS,11′aS)-
• [10b,10′b(11H,11′H)-Bi-3,11a-epidithio-11aH-pyrazino[1′,2′:1,5]pyrrolo[2,3-b]indole]-1,1′,4,4′-tetrone, 2,2′,3,3′,5a,5′a,6,6′-octahydro-3,3′-bis(hydroxymethyl)-2,2′-dimethyl-, [3S-[3α,5aβ,10bβ(3′R*,5′aS*,10′bS*,11′aR*),11aα]]-
• (3S,3'S,5aR,5'aR,10bR,10'bR,11aS,11'aS)-2,2',3,3',5a,5'a,6,6'-Octahydro-3,3'-bis(hydroxymethyl)-2,2'-dimethyl-[10b,10'b(11H,11'H)-bi-3,11a-epidithio-11aH-pyrazino[1',2':1,5]pyrrolo[2,3-b]indole]-1,1',4,4'-tetrone
• CHAETOCIN FROM CHAETOMIUM MINUTUM
• HMTase Inhibitor II, Chaetocin - CAS 28097-03-2 - Calbiochem
• [10b,10'b(11H,11'H)-Bi-3,11a-epidithio-11aH-pyrazino[1',2':1,5]pyrrolo[2,3-b]indole]-1,1',4,4'-tetrone,2,2',3,3',5a,5'a,6,6'-octahydro-3,3'-bis(hydroxymethyl)-2,2'-dimethyl-,(3S,3'S,5aR,5'aR,10bR,10'bR,11aS,11'aS)-
• Chaetocin from Chaetomium minutum >=95% (HPLC)
• CHAETOCIN(SH)
• (3S,3'S,6R,6'R,14R,14'R,16S,16'S)-3,3'-bis(hydroxymethyl)-2,2'-dimethyl-2,2',3,3',6,6',7,7'-octahydro-1H,1'H-[14,14'-bi(3,11a-epidithiopyrazino[1',2':1,5]pyrrolo[2,3-b]indole)]-1,1',4,4'(15H,15'H)-tet
• CHAETOCIN FROM CHAETOMIUM MINUTUM USP/EP/BP
• Chaetocin, 98%, from fungus
• HMTase Inhibitor II, Chaetocin

Chaetocin from Chaetomium minutum

CAS: 28097-03-2

Formula: C₃₀H₂₈N₆O₆S₄

Purity: %

Color and Shape: Solid

Molecular weight: 696.8399

Ref: IN-DA00BEA7

Chaetocin

CAS: 28097-03-2

Formula: C₃₀H₂₈N₆O₆S₄

Purity: ≥ 98.0%

Color and Shape: White to off-white or light yellow powder

Molecular weight: 696.84

Ref: 7W-GL3962

Chaetocin

CAS: 28097-03-2

Chaetocin

Purity: 99%

Color and Shape: Solid

Molecular weight: 696.84g/mol

Ref: 54-BIC0128

Chaetocin

CAS: 28097-03-2

Chaetocin

Purity: ≥98%

Molecular weight: 696.84g/mol

Ref: 54-BUP00380

Chaetocin

CAS: 28097-03-2

Chaetocin: a natural histone methyltransferase inhibitor; IC50 of 0.8, 2.5, and 3 μM for dSU(VAR)3-9, G9a, DIM5.

Formula: C₃₀H₂₈N₆O₆S₄

Purity: 98.36% - 98.82%

Color and Shape: Solid

Molecular weight: 696.84

Ref: TM-T6803

Chetocin

CAS: 28097-03-2

Chetocin is a fungal secondary metabolite, which is a small molecule derived from sources such as Aspergillus and Chaetomium species. With a notable epigenetic mode of action, Chetocin functions as an inhibitor of histone demethylase enzymes, specifically targeting the Jumonji C (JmjC) domain-containing histone demethylases. This inhibition leads to the accumulation of methylated histones, thereby affecting chromatin structure and gene expression.

Formula: C₃₀H₂₈N₆O₆S₄

Purity: Min. 95 Area-%

Color and Shape: Yellow Powder

Molecular weight: 696.84 g/mol

Ref: 3D-FC145218