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CAS 2809982-20-3

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1H,10H-4,8-Metheno-17H-pyrazolo[3′,4′:2,3][1,5,10,12]oxatriazacycloheptadecino[12,11-a]benzimidazol-9-one, 18,19,20,21-tetrahydro-1,6,18-trimethyl-13-(3-oxetanylamino)-, (18R)-

Formula:C27H31N7O3
Synonyms:
  • 1H,10H-4,8-Metheno-17H-pyrazolo[3′,4′:2,3][1,5,10,12]oxatriazacycloheptadecino[12,11-a]benzimidazol-9-one, 18,19,20,21-tetrahydro-1,6,18-trimethyl-13-(3-oxetanylamino)-, (18R)-
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  • EGFR-IN-132
    Targetmol
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    EGFR-IN-132

    CAS:
    EGFR-IN-132 (Compound 23) is an EGFR inhibitor effective against various EGFR mutations including the wild-type, L858R/T790M, d19/T790M, L858R/T790M/C797S, and d19/T790M/C797S with IC50 values of 1.6, 0.025, 0.019, 0.022, and 0.029 nM, respectively. This compound demonstrates favorable pharmacokinetics with high oral bioavailability.
    Formula:C27H31N7O3
    Color and Shape:Solid
    Molecular weight:501.58

    Ref: TM-T201638