CAS 2811663-45-1

(E)-2,6-Di-tertbutyl-4(4-(diethylamino)styryl)pyrylium TFA

CAS: 2811663-45-1

(E)-2,6-Di-tert-butyl-4-(4-(diethylamino)styryl)pyrylium TFA (Compound 4a) functions as a Gram-negative outer membrane permeabilizer by targeting Met47 in LptA to disrupt LptA/LptC interactions, exhibiting synergistic antibacterial activity. This compound, when in the form of (trifluoromethanesulfonate), enhances the efficacy of pol B against both wild-type and multi-drug resistant A. baumannii and E. coli strains. Additionally, (E)-2,6-Di-tert-butyl-4-(4-(diethylamino)styryl)pyrylium (trifluoromethanesulfonate) serves as an adjuvant for antibiotics combating multi-drug resistant Gram-negative bacteria.

Formula: C₂₆H₃₆F₃NO₄S

Color and Shape: Solid

Molecular weight: 515.629

Ref: TM-T205077