CAS 28120-03-8

Tymazoline hydrochloride

Description:

Tymazoline hydrochloride is a pharmaceutical compound primarily used as a topical decongestant. It belongs to the imidazoline class of compounds and functions by stimulating alpha-adrenergic receptors, leading to vasoconstriction and reduced nasal congestion. This substance is typically administered in the form of nasal sprays or drops. Tymazoline hydrochloride is characterized by its white to off-white crystalline powder appearance and is soluble in water, which facilitates its use in aqueous formulations. The compound has a relatively low molecular weight and exhibits a moderate pKa, indicating its weakly basic nature. Its pharmacological effects include rapid onset of action, making it effective for temporary relief of nasal congestion due to colds, allergies, or sinusitis. However, prolonged use can lead to rebound congestion, a phenomenon known as rhinitis medicamentosa. Safety and efficacy profiles are well-documented, but like all medications, it should be used according to medical guidance to avoid potential side effects or complications.

Formula: C₁₄H₂₀N₂O·ClH

InChI: InChI=1S/C14H20N2O.ClH/c1-10(2)12-5-4-11(3)8-13(12)17-9-14-15-6-7-16-14;/h4-5,8,10H,6-7,9H2,1-3H3,(H,15,16);1H

InChI key: InChIKey=DKIDQLUKAZZLAR-UHFFFAOYSA-N

SMILES: O(CC=1NCCN1)C2=C(C(C)C)C=CC(C)=C2.Cl

Synonyms:

• 1H-Imidazole, 4,5-dihydro-2-[[5-methyl-2-(1-methylethyl)phenoxy]methyl]-, hydrochloride (1:1)
• 1H-Imidazole, 4,5-dihydro-2-[[5-methyl-2-(1-methylethyl)phenoxy]methyl]-, monohydrochloride
• 2-((2-Isopropyl-5-methylphenoxy)methyl)-4,5-dihydro-1H-imidazole hydrochloride
• 2-(Thymyloxymethyl)glyoxalidine hydrochloride
• 2-Imidazoline, 2-(thymloxy)-, hydrochloride
• 2-Imidazoline, 2-[(thymyloxy)methyl]-, monohydrochloride
• 2-Thymoxymethylimidazoline hydrochloride
• 2-{[5-methyl-2-(propan-2-yl)phenoxy]methyl}-4,5-dihydro-1H-imidazol-1-ium chloride
• Thymazen
• Tymazoline hydrochloride
• 4,5-Dihydro-2-((2-isopropyl-5-methylphenoxy)methyl)-1H-imidazole monohydrochloride

Tymazoline Hydrochloride

Controlled Product

CAS: 28120-03-8

Stability Hygroscopic
Applications Tymazoline Hydrochloride shows antihistamine and antibacterial properties in research.
References Chlopkiewicz, B.: et al.: Biul. Inf. Inst. Lek., 30, 157 (1983); Marrero-Ponce, . et al.: Bioorg. Med. Chem., 13, 2881 (2005);

Formula: C₁₄H₂₀N₂O·ClH

Color and Shape: Neat

Molecular weight: 268.78

Ref: TR-T898250

Tymazoline hydrochloride

CAS: 28120-03-8

Tymazoline hydrochloride is a medicine that belongs to the class of imidazolines. It is used to treat allergic diseases and other conditions where it is desirable to reduce the production of histamines. Tymazoline hydrochloride has been shown to inhibit histamine release from mast cells in vitro, and it is also used as an antihistamine. Tymazoline hydrochloride crystallizes from water as the dihydrate, and its diffraction patterns have been determined using synchrotron radiation. The molecule has an orthorhombic crystal structure with spacings of 0.7-0.8 nm between planes and intensities of 5-6 cm-1 in the X-ray region. Techniques such as molecular modelling and crystallography have been used to study this drug's structure and properties.

Formula: C₁₄H₂₁ClN₂O

Purity: Min. 95%

Molecular weight: 268.78 g/mol

Ref: 3D-DBA12003