CAS 2823-42-9

(6α,11β,16α)-21-(Acetyloxy)-6,9-difluoro-11,17-dihydroxy-16-methylpregna-1,4-diene-3,20-dione

Description:

The chemical substance known as (6α,11β,16α)-21-(Acetyloxy)-6,9-difluoro-11,17-dihydroxy-16-methylpregna-1,4-diene-3,20-dione, with the CAS number 2823-42-9, is a synthetic corticosteroid. It exhibits anti-inflammatory and immunosuppressive properties, making it useful in various therapeutic applications, particularly in treating conditions like asthma, allergies, and autoimmune disorders. The structure of this compound features a steroid backbone with multiple functional groups, including acetoxy, difluoro, and hydroxy groups, which contribute to its biological activity and pharmacokinetics. The presence of fluorine atoms enhances its potency and metabolic stability. As a corticosteroid, it mimics the effects of natural hormones produced by the adrenal glands, influencing numerous physiological processes such as metabolism, immune response, and stress response. Its specific stereochemistry is crucial for its interaction with glucocorticoid receptors, determining its efficacy and safety profile in clinical use. Overall, this compound represents a significant advancement in steroid chemistry, providing a valuable tool in modern medicine.

Formula: C₂₄H₃₀F₂O₆

InChI: InChI=1S/C24H30F2O6/c1-12-7-15-16-9-18(25)17-8-14(28)5-6-21(17,3)23(16,26)19(29)10-22(15,4)24(12,31)20(30)11-32-13(2)27/h5-6,8,12,15-16,18-19,29,31H,7,9-11H2,1-4H3/t12-,15+,16+,18+,19+,21+,22+,23+,24+/m1/s1

InChI key: InChIKey=ISSQQUKLQJHHOR-OSNGSNEUSA-N

SMILES: C[C@@]12[C@]([C@]3([C@@](F)([C@]4(C)C([C@@H](F)C3)=CC(=O)C=C4)[C@@H](O)C1)[H])(C[C@@H](C)[C@@]2(C(COC(C)=O)=O)O)[H]

Synonyms:

• (6Alpha,8Xi,10Xi,11Beta,13Xi,16Alpha)-6,9-Difluoro-11,21-Dihydroxy-16-Methyl-3,20-Dioxopregna-1,4-Dien-17-Yl Acetate
• (6α,11β,16α)-21-(Acetyloxy)-6,9-difluoro-11,17-dihydroxy-16-methylpregna-1,4-diene-3,20-dione
• 6α-Fluorodexamethasone 21-acetate
• Flumetasone 21-acetate
• Flumethasone 21-acetate
• Flumethasone Acetate
• Pregna-1,4-diene-3,20-dione, 21-(acetyloxy)-6,9-difluoro-11,17-dihydroxy-16-methyl-, (6α,11β,16α)-
• Pregna-1,4-diene-3,20-dione, 6α,9-difluoro-11β,17,21-trihydroxy-16α-methyl-, 21-acetate

Flumethasone 17-Acetate

CAS: 2823-42-9

Formula: C₂₄H₃₀F₂O₆

Molecular weight: 452.50

Ref: 4Z-F-705

Flumethasone 21-acetate

CAS: 2823-42-9

Flumethasone 21-acetate is an anti-inflammatory corticosteroid.

Formula: C₂₄H₃₀F₂O₆

Color and Shape: Solid

Molecular weight: 452.49

Ref: TM-T21190

Flumethasone acetate

Controlled Product

CAS: 2823-42-9

Flumethasone acetate is a synthetic corticosteroid that has anti-inflammatory, antipruritic, and vasoconstrictive properties. It is used in the treatment of various skin disorders, including psoriasis, eczema and atopic dermatitis. Flumethasone acetate binds to the cytosolic glucocorticoid receptor (GR) and inhibits the transcription of genes that encode proteins involved in inflammation. The drug also has potent anti-inflammatory activity, but lacks the mineralocorticoid activity of hydrocortisone or cortisone. Flumethasone acetate does not bind significantly to the sex hormone binding globulin (SHBG), which is important for its use in females as it will not interfere with estrogen production.

Formula: C₂₄H₃₀F₂O₆

Purity: Min. 95%

Color and Shape: White/Off-White Solid

Molecular weight: 452.49 g/mol

Ref: 3D-FF23330

Flumethasone-d3 Acetate

Controlled Product

CAS: 2823-42-9

Applications Labelled Flumethasone Acetate (F455005). An anti-inflammatory corticosteroid.
References Weber, D., et al.: J. Pharm. Sci., 61, 689 (1972), Biagi, G., et al.: J. Med. Chem., 18, 873 (1975)

Formula: C₂₄D₃H₂₇F₂O₆

Color and Shape: Neat

Molecular weight: 455.507

Ref: TR-F455007

Flumethasone Acetate

Controlled Product

CAS: 2823-42-9

Applications An anti-inflammatory corticosteroid.
References Weber, D., et al.: J. Pharm. Sci., 61, 689 (1972), Biagi, G., et al.: J. Med. Chem., 18, 873 (1975),

Formula: C₂₄H₃₀F₂O₆

Color and Shape: Neat

Molecular weight: 452.49

Ref: TR-F455005

Flumethasone 17-Acetate

CAS: 2823-42-9

Formula: C₂₄H₃₀F₂O₆

Molecular weight: 452.5

Ref: ST-EA-CP-F28004