CAS 2832061-40-0

Lipid PPz-2R1

Description:

Lipid PPz-2R1 is an ionizable cationic lipid that has been used in the generation of lipid nanoparticles (LNPs) for the delivery of mRNA in vitro and in vivo.1 LNPs containing lipid PPz-2R1 and encapsulating an mRNA reporter selectively accumulate in lungs over the heart, liver, spleen, and kidneys in mice. LNPs containing lipid PPz-2R1 and encapsulating mRNA encoding phosphatase and tensin homolog (PTEN) increase PTEN protein levels in PTEN-deficient Lewis lung carcinoma (LLC) cells. Lipid PPz-2R1-containing LNPs encapsulating PTEN mRNA reduce tumor growth in an orthotopic murine LLC model when administered alone or in combination with an antibody targeting programmed cell death protein 1 (PD-1).WARNING This product is not for human or veterinary use.

Synonyms:

• Lipid PPz-2R1

Lipid PPz-2R1

CAS: 2832061-40-0

Lipid PPz-2R1 is an ionizable cationic lipid employed in crafting lipid nanoparticles (LNPs) for mRNA delivery both in vitro and in vivo. LNPs with lipid PPz-2R1, encapsulating an mRNA reporter, target the lungs preferentially over the heart, liver, spleen, and kidneys in mice. Additionally, these LNPs, when encapsulating mRNA encoding phosphatase and tensin homolog (PTEN), enhance PTEN protein levels in PTEN-deficient Lewis lung carcinoma (LLC) cells. In an orthotopic murine LLC model, these Lipid PPz-2R1-containing LNPs, carrying PTEN mRNA, reduce tumor growth either when administered alone or alongside an antibody against programmed cell death protein 1 (PD-1).

Formula: C₄₈H₉₄N₂O₄

Color and Shape: Solid

Molecular weight: 763.27

Ref: TM-TCL-01231