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CAS 2834094-36-7

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  • PD-L1/HDAC6-IN-1
    Targetmol
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    PD-L1/HDAC6-IN-1

    CAS:
    <p>PD-L1/HDAC6-IN-1 (Compound HP29) is an inhibitor targeting both PD-L1 and HDAC6, effectively disrupting the PD-L1/PD-1 interaction and inhibiting HDAC6 activity, with IC50 values of 26.8 nM and 69 nM, respectively. This compound enhances the cytotoxicity of Jurkat T cells against HepG2 cells, exhibiting an IC50 of 3.4 μM. In rats, PD-L1/HDAC6-IN-1 demonstrates favorable pharmacokinetics, showing a drug exposure level of 871.62 ng·h/mL, and displays antitumor activity in a B16-F10 xenograft mouse model.</p>
    Formula:C27H33N3O3
    Color and Shape:Solid
    Molecular weight:447.569

    Ref: TM-T205403