CAS 28395-03-1
:Bumetanide
Description:
Bumetanide is a potent loop diuretic primarily used in the management of edema associated with heart failure, liver cirrhosis, and renal disease. It functions by inhibiting the sodium-potassium-chloride co-transporter in the thick ascending limb of the loop of Henle in the kidneys, leading to increased excretion of sodium, chloride, and water. This results in diuresis, which helps reduce fluid overload. Bumetanide is characterized by its high bioavailability and rapid onset of action, making it effective for acute situations. It is typically administered orally or intravenously, and its effects can be observed within an hour of administration. The substance has a relatively short half-life, necessitating multiple doses for sustained effect. Common side effects include electrolyte imbalances, dehydration, and potential ototoxicity, particularly at higher doses. Due to its potency, careful monitoring of renal function and electrolyte levels is essential during treatment. Bumetanide is classified as a sulfonamide, and its chemical structure includes a butyl group, contributing to its pharmacological properties.
Formula:C17H20N2O5S
InChI:InChI=1S/C17H20N2O5S/c1-2-3-9-19-14-10-12(17(20)21)11-15(25(18,22)23)16(14)24-13-7-5-4-6-8-13/h4-8,10-11,19H,2-3,9H2,1H3,(H,20,21)(H2,18,22,23)
InChI key:InChIKey=MAEIEVLCKWDQJH-UHFFFAOYSA-N
SMILES:O(C1=C(NCCCC)C=C(C(O)=O)C=C1S(N)(=O)=O)C2=CC=CC=C2
Synonyms:- 3-(Aminosulfonyl)-5-(butylamino)-4-phenoxybenzoic acid
- 3-(Butylamino)-4-phenoxy-5-sulfamoylbenzoic acid
- 3-n-Butylamino-4-phenoxy-5-sulfamoylbenzoic acid
- Benzoic acid, 3-(butylamino)-4-phenoxy-5-sulfamoyl-
- Bufenox
- Bumetanid
- Bumetanida
- Bumetanide
- Bumethanide
- Bumex
- Burinex
- Edemex
- Fontego
- Fordiuran
- Lixil
- Lunetoron
- Pf 1593
- Ro 10-6338
- Benzoic acid, 3-(aminosulfonyl)-5-(butylamino)-4-phenoxy-
- See more synonyms
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Found 13 products.
Bumetanide, 98+%
CAS:<p>Inhibitor of the sodium-potassium-chloride cotransporter</p>Formula:C17H20N2O5SPurity:98+%Molecular weight:364.4Bumetanide
CAS:BumetanideFormula:C17H20N2O5SPurity:99.9%Color and Shape:White SolidMolecular weight:364.10929Bumetanide
CAS:Sulfonamides used as drugsFormula:C17H20N2O5SColor and Shape:White Crystalline PowderMolecular weight:364.10929Bumetanide
CAS:<p>Bumetanide (PF 1593) is a potent sulfamoylanthranilic acid derivative belonging to the class of loop diuretics. In the brain, bumetanide may prevent seizures in neonates by blocking the bumetanide-sensitive sodium-potassium-chloride cotransporter (NKCC1), thereby inhibiting chloride uptake thus, decreasing the internal chloride concentration in neurons and may block the excitatory effect of GABA in neonates.</p>Formula:C17H20N2O5SPurity:99.82% - 99.9%Color and Shape:SolidMolecular weight:364.42Bumetanide
CAS:Formula:C17H20N2O5SPurity:≥ 98.0%Color and Shape:White to off-white powderMolecular weight:364.40Bumetanide
CAS:Controlled ProductFormula:C17H20N2O5SColor and Shape:Light YellowMolecular weight:364.42Bumetanide
CAS:Controlled Product<p>Bumetanide is a diuretic that inhibits the response of the airways to bronchoconstrictor drugs. It has been shown to inhibit the production of IL-2 receptor in human serum and cytosolic Ca2+ release from cells, leading to neuronal death. Bumetanide also inhibits axonal growth and whole-cell recordings in rat neurons. In addition, bumetanide has been shown to have inhibitory binding on pharmacological agents that are used for congestive heart failure treatment.</p>Formula:C17H20N2O5SPurity:Min. 98 Area-%Color and Shape:PowderMolecular weight:364.42 g/mol3-(Butylamino)-4-phenoxy-5-sulfamoylbenzoic acid
CAS:Formula:C17H20N2O5SPurity:98%Color and Shape:SolidMolecular weight:364.4161Ref: IN-DA00383X
Discontinued product
