CAS 284028-89-3

XAV-939

Description:

XAV-939, identified by its CAS number 284028-89-3, is a small molecule inhibitor primarily known for its role in the modulation of the Wnt signaling pathway. This compound has garnered attention in the field of cancer research due to its ability to inhibit the activity of tankyrase enzymes, which are involved in the regulation of β-catenin, a key player in the Wnt signaling cascade. By disrupting this pathway, XAV-939 can potentially suppress the proliferation of certain cancer cells that rely on Wnt signaling for growth and survival. In addition to its anticancer properties, XAV-939 has been studied for its effects on stem cell differentiation and tissue regeneration. The compound is typically characterized by its chemical structure, which includes specific functional groups that contribute to its biological activity. As with many experimental compounds, further research is ongoing to fully elucidate its mechanisms of action, therapeutic potential, and any associated side effects.

XAV 939

CAS: 284028-89-3

Formula: C₁₄H₁₁F₃N₂OS

Purity: >98.0%(HPLC)

Color and Shape: White to Almost white powder to crystal

Molecular weight: 312.31

Ref: 3B-X0077

3,5,7,8-Tetrahydro-2-[4-(trifluoromethyl)phenyl]-4H-thiopyrano[4,3-d]pyrimidin-4-one

CAS: 284028-89-3

Formula: C₁₄H₁₁F₃N₂OS

Purity: 98%

Color and Shape: Solid

Molecular weight: 312.3101

Ref: IN-DA0039F6

XAV-939

CAS: 284028-89-3

XAV-939

Purity: ≥95%

Molecular weight: 312.31g/mol

Ref: 54-BUP15551

2-[4-(Trifluoromethyl)phenyl]-1,5,7,8-tetrahydrothiopyrano[4,3-d]pyrimidin-4-one

CAS: 284028-89-3

2-[4-(Trifluoromethyl)phenyl]-1,5,7,8-tetrahydrothiopyrano[4,3-d]pyrimidin-4-one

Purity: 98%

Molecular weight: 312.31g/mol

Ref: 54-PC50918

XAV939

CAS: 284028-89-3

Formula: C₁₄H₁₁F₃N₂OS

Molecular weight: 312.31

Ref: 7W-GL3551

XAV-939

CAS: 284028-89-3

Formula: C₁₄H₁₁F₃N₂OS

Molecular weight: 312.31

Ref: 4Z-X-019001

XAV-939

CAS: 284028-89-3

XAV-939 (NVP-XAV939) shows the selective inhibition against Wnt/β-catenin-mediated transcription by tankyrase1/2 inhibition (IC50: 11/4 nM in cell-free assay).

Formula: C₁₄H₁₁F₃N₂OS

Purity: 97.47% - 99.67%

Color and Shape: Solid

Molecular weight: 312.31

Ref: TM-T1878

XAV 939

Controlled Product

CAS: 284028-89-3

Applications A tankyrase (TNKS) inhibitor that antagonizes Wnt signaling via stimulation of β-catenin degradation and stabilization of axin. XAV 939 inhibits proliferation of the μ-catenin-dependent colon carcinoma cell line DLD-1.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Huang, S. et al.: Nature, 461, 614 (2009); Wang, H. et al.: ACS Chem. Biol., 6, 192 (2011); Adles, M.E. et al.: Sci. Signal., 91, ec326 (2009);

Formula: C₁₄H₁₁F₃N₂OS

Color and Shape: Neat

Molecular weight: 312.31

Ref: TR-X744000

XAV 939

CAS: 284028-89-3

Inhibits tankyrase (TNKS1 and TNKS2 with IC50 values of 11 and 4 nM respectively), by binding to the catalytic poly-ADP-ribose polymerase (PARP) domain. This stabilizes cytoplasmic protein Axin, mediating β-catenin depletion and thereby suppresses Wnt signalling pathway. XAV 939 has anti-proliferative and pro-apoptotic effects on neuroblastoma and colorectal cancer cells.

Formula: C₁₄H₁₁F₃N₂OS

Purity: Min. 95%

Molecular weight: 312.31 g/mol

Ref: 3D-FX28737