CAS 284035-33-2

2-Chloro-6-[(2R)-3-[[1,1-dimethyl-2-(2-naphthalenyl)ethyl]amino]-2-hydroxypropoxy]benzonitrile

Description:

2-Chloro-6-[(2R)-3-[[1,1-dimethyl-2-(2-naphthalenyl)ethyl]amino]-2-hydroxypropoxy]benzonitrile, with CAS number 284035-33-2, is a synthetic organic compound characterized by its complex structure, which includes a chloro group, a benzonitrile moiety, and a hydroxypropoxy side chain. This compound is typically classified as a pharmaceutical intermediate or active ingredient, often associated with specific therapeutic applications. Its molecular structure suggests potential interactions with biological targets, particularly in the context of receptor binding or enzyme inhibition. The presence of the naphthalene ring indicates hydrophobic characteristics, which may influence its solubility and bioavailability. Additionally, the compound's chirality, indicated by the (2R) configuration, suggests that it may exhibit stereoselective properties in biological systems. Overall, the characteristics of this compound, including its functional groups and stereochemistry, contribute to its potential efficacy and safety profile in medicinal chemistry.

Formula: C₂₄H₂₅ClN₂O₂

InChI: InChI=1/C24H25ClN2O2/c1-24(2,13-17-10-11-18-6-3-4-7-19(18)12-17)27-15-20(28)16-29-23-9-5-8-22(25)21(23)14-26/h3-12,20,27-28H,13,15-16H2,1-2H3/t20-/m1/s1

InChI key: InChIKey=PZUJQWHTIRWCID-HXUWFJFHSA-N

SMILES: C(C(NC[C@H](COC1=C(C#N)C(Cl)=CC=C1)O)(C)C)C2=CC3=C(C=C2)C=CC=C3

Synonyms:

• 2-Chloro-6-[(2R)-2-hydroxy-3-[(2-methyl-1-naphthalen-2-ylpropan-2-yl)amino]propoxy]benzonitrile
• 2-Chloro-6-{[(2R)-2-hydroxy-3-{[2-methyl-1-(2-naphthyl)propan-2-yl]amino}propyl]oxy}benzonitrile
• 2-chloro-6-({(2R)-3-[(1,1-dimethyl-2-naphthalen-2-ylethyl)amino]-2-hydroxypropyl}oxy)benzonitrile
• 2-chloro-6-{[(2R)-2-hydroxy-3-{[2-methyl-1-(naphthalen-2-yl)propan-2-yl]amino}propyl]oxy}benzonitrile
• Benzonitrile, 2-chloro-6-[(2R)-3-[[1,1-dimethyl-2-(2-naphthalenyl)ethyl]amino]-2-hydroxypropoxy]-
• Nps 2143
• Sb 262470
• Sb 262470A
• benzonitrile, 2-chloro-6-[[(2R)-3-[[1,1-dimethyl-2-(2-naphthalenyl)ethyl]amino]-2-hydroxypropyl]oxy]-
• 2-Chloro-6-[(2R)-3-[[1,1-dimethyl-2-(2-naphthalenyl)ethyl]amino]-2-hydroxypropoxy]benzonitrile
• NPS 2143 USP/EP/BP
• SB262470
• SB-262470(NPS-2143)
• NPS-2143(SB 262470A )
• 2-Chloro-6-[3-[1, 1-dimethyl-2-(2-naphthyl)ethylamino]-2(R)-hydroxypropoxy]benzonitrile(NPS 2143)
• CS-1600
• NPS-2143 (SB-262470)
• NPS 2143;SB 262470A;NPS2143;SB262470
• 2-Chloro-6-[3-[1, 1-diMethyl-2-(2-naphthyl)ethylaMino]-2(R)-hydroxypropoxy]benzonitrile
• 2-Chloro-6-[3-[1, 1-dimethyl-2-(2-naphthyl)ethylamino]-2(R)-hydroxypropoxy]benzonitrile(NPS 2
• 2-chloro-6-[(2R)-3-[[1
• NPS-2143 base
• 1-diMethyl-2-(2-naphthalenyl)ethyl]aMino]-2-hydroxypropoxy]-
• (R)-2-chloro-6-(2-hydroxy-3-(2-methyl-1-(naphthalen-2-yl)propan-2-ylamino)propoxy)benzonitrile
• NPS 2143 hydrochloride(SB-262470)
• NPS 2143; SB 262470A ; NPS2143
• NPS 2143, SB262470 hydrochloride
• NPS-2143;NPS 2143; SB 262470A; NPS2143
• CS-276

2-Chloro-6-[(2R)-3-[[1,1-dimethyl-2-(2-naphthalenyl)ethyl]amino]-2-hydroxypropoxy]benzonitrile

CAS: 284035-33-2

Formula: C₂₄H₂₅ClN₂O₂

Purity: 98%

Molecular weight: 408.9205

Ref: IN-DA007KOE

NPS-2143

CAS: 284035-33-2

NPS-2143

Purity: ≥98%

Molecular weight: 408.92g/mol

Ref: 54-BUP10169

NPS-2143

CAS: 284035-33-2

NPS-2143 is a small molecule that enhances the mitochondrial membrane potential by regulating intracellular calcium levels. It also prevents the loss of energy metabolism and pathogenic mechanisms of cells. NPS-2143 is a competitive antagonist to the calcium-sensing receptor, which is responsible for sensing extracellular and cytosolic calcium levels. This drug has been shown to inhibit leukocyte recruitment and inflammation in the lungs, as well as inhibiting platelet aggregation. NPS-2143 binds to basic proteins and peptide hormones, such as angiotensin II, erythropoietin, follicle stimulating hormone (FSH), luteinizing hormone (LH), insulin, prolactin, growth hormone (GH), parathyroid hormone (PTH), thyroid stimulating hormone (TSH), somatostatin, vasopressin, calcitonin, glucagon, and secretin.

Formula: C₂₄H₂₅ClN₂O₂

Purity: Min. 95%

Molecular weight: 408.92 g/mol

Ref: 3D-JLA03533

NPS-2143

CAS: 284035-33-2

NPS-2143 (SB 262470A) is a novel potent and selective antagonist of Ca(2+) receptor.

Formula: C₂₄H₂₅ClN₂O₂

Purity: 99.56%

Color and Shape: Solid

Molecular weight: 408.92

Ref: TM-T1730