CAS 284461-73-0: Sorafenib

Description: Sorafenib is a small-molecule tyrosine kinase inhibitor primarily used in the treatment of certain types of cancer, including renal cell carcinoma and hepatocellular carcinoma. Its chemical formula is C21H16ClF2N3O3, and it features a complex structure that includes a pyridine ring, a phenyl group, and a urea moiety. Sorafenib functions by inhibiting multiple kinases involved in tumor cell proliferation and angiogenesis, specifically targeting the RAF kinase and various receptor tyrosine kinases. This multi-targeted approach helps to disrupt the signaling pathways that promote cancer growth and metastasis. Sorafenib is typically administered orally and has a moderate bioavailability, with its pharmacokinetics influenced by factors such as food intake. Common side effects include fatigue, diarrhea, and skin reactions. Due to its mechanism of action and therapeutic applications, Sorafenib represents a significant advancement in targeted cancer therapies, although its use may be limited by the development of resistance and the need for careful patient monitoring.

Formula: C₂₁H₁₆ClF₃N₄O₃

InChI: InChI=1S/C21H16ClF3N4O3/c1-26-19(30)18-11-15(8-9-27-18)32-14-5-2-12(3-6-14)28-20(31)29-13-4-7-17(22)16(10-13)21(23,24)25/h2-11H,1H3,(H,26,30)(H2,28,29,31)

InChI key: InChIKey=MLDQJTXFUGDVEO-UHFFFAOYSA-N

SMILES: O=C(NC1=CC=C(OC=2C=CN=C(C2)C(=O)NC)C=C1)NC3=CC=C(Cl)C(=C3)C(F)(F)F

Synonyms:

• 2-Pyridinecarboxamide, 4-[4-[[[[4-chloro-3-(trifluoromethyl)phenyl]amino]carbonyl]amino]phenoxy]-N-methyl-
• 4-[4-({[4-chloro-3-(trifluoromethyl)phenyl]carbamoyl}amino)phenoxy]-N-methylpyridine-2-carboxamide
• 4-[4-({[4-chloro-3-(trifluoromethyl)phenyl]carbamoyl}amino)phenoxy]-N-methylpyridine-2-carboxamide 4-methylbenzenesulfonate
• 4-[4-[[4-Chloro-3-(trifluoromethyl)phenyl]carbamoylamino]phenoxy]-N-methyl-pyridine-2-carboxamide
• 4-[4-[[[[4-chloro-3-(trifluoromethyl)phenyl]amino]carbonyl]amino]phenoxy]-N-methyl-2-Pyridinecarboxamide
• Bay 43-9006
• N-[4-Chloro-3-(trifluoromethyl)phenyl]-N'-[4-[2-(N-methylcarbamoyl)-4-pyridyloxy]phenyl]urea
• Nevaxar
• Sorafenib base
• Sorafenib

Sorafenib

CAS: 284461-73-0

• Formula: C₂₁H₁₆ClF₃N₄O₃
• Purity: >98.0%(T)(HPLC)
• Color and Shape: White to Light yellow powder to crystal
• Molecular weight: 464.83

4-[4-[[[[4-Chloro-3-(trifluoromethyl)phenyl]amino]carbonyl]amino]phenoxy]-N-methyl-2-pyridinecarboxamide

CAS: 284461-73-0

• Formula: C₂₁H₁₆ClF₃N₄O₃
• Purity: 99%
• Color and Shape: Solid
• Molecular weight: 464.8249

Sorafenib

CAS: 284461-73-0

Sorafenib (Bay 43-9006) is a multikinase inhibitor that inhibits Raf-1, B-Raf, VEGFR2, VEGFR3, VEGFR4, PDGFRβ, …

• Formula: C₂₁H₁₆ClF₃N₄O₃
• Purity: 98% - 99.89%
• Color and Shape: Solid
• Molecular weight: 464.82

Sorafenib

CAS: 284461-73-0

• Formula: C₂₁H₁₆ClF₃N₄O₃
• Purity: 99% (nmr) (Typical Value in Batch COA)
• Color and Shape: white solid
• Molecular weight: 464.82g/mol

Sorafenib

CAS: 284461-73-0

• Purity: 99.69%
• Molecular weight: 464.82g/mol

Sorafenib

CAS: 284461-73-0

• Formula: C₂₁H₁₆ClF₃N₄O₃
• Color and Shape: White To Off-White Solid
• Molecular weight: 464.83

Sorafenib

CAS: 284461-73-0

• Formula: C₂₁H₁₆ClF₃N₄O₃
• Purity: ≥ 95.0%
• Color and Shape: White, off-white or light-yellow solid
• Molecular weight: 464.83

Sorafenib

CAS: 284461-73-0

• Formula: C₂₁H₁₆ClF₃N₄O₃
• Color and Shape: Neat
• Molecular weight: 464.82

Sorafenib-d4

CAS: 284461-73-0

• Formula: C₂₁H₁₂ClF₃N₄O₃D₄
• Molecular weight: 468.86

Sorafenib-d4

CAS: 284461-73-0

• Formula: C₂₁H₁₂D₄ClF₃N₄O₃
• Color and Shape: Neat
• Molecular weight: 468.85

Sorafenib

CAS: 284461-73-0

• Formula: C₂₁H₁₆ClF₃N₄O₃
• Color and Shape: White Solid
• Molecular weight: 464.82

Sorafenib - Bio-X ™

CAS: 284461-73-0

Sorafenib is a drug that belongs to the class of multikinase inhibitors. It inhibits a …

• Formula: C₂₁H₁₆ClF₃N₄O₃
• Purity: Min. 98%
• Color and Shape: Powder
• Molecular weight: 464.82 g/mol

Sorafenib

CAS: 284461-73-0

Sorafenib is a drug that belongs to the class of multikinase inhibitors. It inhibits a …

• Formula: C₂₁H₁₆ClF₃N₄O₃
• Purity: Min. 98.0 Area-%
• Color and Shape: White Powder
• Molecular weight: 464.82 g/mol