CAS 284461-74-1

4-[4-[[[[4-Chloro-3-(trifluoromethyl)phenyl]amino]carbonyl]amino]phenoxy]-2-pyridinecarboxamide

Description:

4-[4-[[[[4-Chloro-3-(trifluoromethyl)phenyl]amino]carbonyl]amino]phenoxy]-2-pyridinecarboxamide, with CAS number 284461-74-1, is a synthetic organic compound characterized by its complex molecular structure, which includes multiple functional groups such as amides and phenoxy groups. This compound features a chloro-substituted trifluoromethyl phenyl moiety, contributing to its potential biological activity and lipophilicity. The presence of a pyridine ring enhances its chemical reactivity and solubility in various solvents. Typically, compounds of this nature are investigated for their pharmacological properties, including potential applications in medicinal chemistry, particularly in the development of therapeutic agents. The specific arrangement of atoms and functional groups suggests that it may interact with biological targets, making it of interest in drug discovery. Additionally, its stability and reactivity can be influenced by environmental factors such as pH and temperature, which are crucial for understanding its behavior in biological systems.

Formula: C₂₀H₁₄ClF₃N₄O₃

InChI: InChI=1S/C20H14ClF3N4O3/c21-16-6-3-12(9-15(16)20(22,23)24)28-19(30)27-11-1-4-13(5-2-11)31-14-7-8-26-17(10-14)18(25)29/h1-10H,(H2,25,29)(H2,27,28,30)

InChI key: InChIKey=UAEWBZYTKIMYRQ-UHFFFAOYSA-N

SMILES: O(C=1C=C(C(N)=O)N=CC1)C2=CC=C(NC(NC3=CC(C(F)(F)F)=C(Cl)C=C3)=O)C=C2

Synonyms:

• 4-[4-[[[[4-Chloro-3-(trifluoromethyl)phenyl]amino]carbonyl]amino]phenoxy]-2-pyridinecarboxamide
• BAY 43-9007
• 2-Pyridinecarboxamide, 4-[4-[[[[4-chloro-3-(trifluoromethyl)phenyl]amino]carbonyl]amino]phenoxy]-
• N-Desmethylsorafenib
• N-[4-Chloro-3-(trifluoromethyl)phenyl]-N′-[4-(2-carbamoyl-4-pyridyloxy)phenyl]urea

4-(4-(3-(4-Chloro-3-(trifluoromethyl)phenyl)ureido)phenoxy)picolinamide

CAS: 284461-74-1

4-(4-(3-(4-Chloro-3-(trifluoromethyl)phenyl)ureido)phenoxy)picolinamide

Purity: 98%

Molecular weight: 450.8g/mol

Ref: 54-PC1007978

N-Desmethyl Sorafenib

CAS: 284461-74-1

Color and Shape: Neat

Ref: 86-MM3585.05

Sorafenib Related Compound 14

CAS: 284461-74-1

Formula: C₂₀H₁₄ClF₃N₄O₃

Molecular weight: 450.81

Ref: 4Z-S-2722

N-Desmethyl Sorafenib

Controlled Product

CAS: 284461-74-1

Applications N-Desmethyl Sorafenib is a metabolite of Sorafenib (S676850) and has anti-proliferative activity in human breast cancer cells.
References Cui, P.H., et al.: Biochem. Pharmacol., 86, 419 (2013); Ghassabian, S., et al.: Biochem. Pharmacol., 84, 215 (2012)

Formula: C₂₁H₁₅ClF₃N₃O₃

Color and Shape: Light Red

Molecular weight: 449.81

Ref: TR-D293290

N-Desmethyl sorafenib

CAS: 284461-74-1

N-desmethyl sorafenib is an analytical standard for the HPLC assay of sorafenib. It is a metabolite of sorafenib, which is a drug used in the treatment of cancer. It has been shown to inhibit protein synthesis and cell growth in vitro and in vivo. N-desmethyl sorafenib has been shown to inhibit the activity of methionine adenosyltransferase, leading to inhibition of DNA synthesis. The chemical properties are similar to those of other drugs that have been approved by the US Food and Drug Administration.

Formula: C₂₀H₁₄ClF₃N₄O₃

Purity: Min. 95%

Molecular weight: 450.80 g/mol

Ref: 3D-JLA46174

N-Desmethyl Sorafenib

CAS: 284461-74-1

Formula: C₂₀H₁₄ClF₃N₄O₃

Molecular weight: 450.80

Ref: ST-EA-CP-S16020