CAS 284462-37-9

4-(4-Aminophenoxy)-N-methylpicolinamide

Description:

4-(4-Aminophenoxy)-N-methylpicolinamide, identified by its CAS number 284462-37-9, is a chemical compound that features a picolinamide structure with an aminophenoxy group. This compound typically exhibits characteristics such as being a solid at room temperature, with potential applications in medicinal chemistry due to its structural motifs that may interact with biological targets. The presence of the amino group suggests it may participate in hydrogen bonding, enhancing its solubility in polar solvents. Additionally, the methyl group on the nitrogen atom can influence its lipophilicity and overall pharmacokinetic properties. The compound may also exhibit specific reactivity patterns typical of amides and aromatic compounds, making it of interest for further research in drug development or as a chemical probe in biological studies. Its synthesis and characterization would involve standard organic chemistry techniques, and its stability and reactivity would depend on the surrounding conditions, such as pH and temperature.

Formula: C₁₃H₁₃N₃O₂

InChI: InChI=1S/C13H13N3O2/c1-15-13(17)12-8-11(6-7-16-12)18-10-4-2-9(14)3-5-10/h2-8H,14H2,1H3,(H,15,17)

InChI key: InChIKey=RXZZBPYPZLAEFC-UHFFFAOYSA-N

SMILES: O(C=1C=C(C(NC)=O)N=CC1)C2=CC=C(N)C=C2

Synonyms:

• 2-Pyridinecarboxamide, 4-(4-aminophenoxy)-N-methyl-
• 4-(4-Aminophenoxy)-N-methyl-2-pyridinecarboxamide
• 4-(4-Aminophenoxy)-N-methylpicolin Amide
• 4-(4-Aminophenoxy)pyridine-2-carboxylic acid methylamide
• 4-(4-aminophenoxy)-N-methylpyridine-2-carboxamide
• 4-[2-(N-Methylcarbamyl)-4-pyridyloxy]aniline
• 4-[[2-(Methylcarbamoyl)pyridin-4-yl]oxy]aniline
• 4-[[2-(N-Methylcarbamoyl)-4-pyridyl]oxy]aniline
• 4-[[2-(N-Methylcarbamoyl)pyridin-4-yl]oxy]aniline
• N-Methyl-4-(4-aminophenoxy)pyridine-2-carboxamide
• [4-(4-Aminophenoxy)(2-Pyridyl)]-N-Methylcarboxamide
• [4-(4-Aminophenoxy-2-pyridyl)]
• 4-(4-aminophenoxy)-N-methylpyridine-2-carboxamide oxalate
• 4-(4-Aminophenyloxy)-N-methyl-2-pyridininecarboxamide
• Sorafenib INT2
• 4-(4-Aminophenoxy)-N-methylpicolinamide
• 4-(4-aMiNApheNAxy)-N-MethylpicolinaMide
• [4-(4-Aminophenoxy-2-pyridyl)]-2-methylcarboxamide
• 4-(4- aMinophenoxy)-N- Methyl-2- pyridineforMaMide
• 4-(4-AMinophenoxy)-pyridine-2-carboxylic acid aMide
• Sorafenib impurity A
• 4-[[2-(N-Methylcarbamoyl)-4-pyridyl]oxy]anilin
• 4-(4-Aminophenoxy)-N-methylpicolimide
• 4-(4-AMino-phenoxy)-pyridine-2-carboxylicacidMethylaMide

4-(4-Aminophenoxy)-N-methyl-2-pyridinecarboxamide

CAS: 284462-37-9

Formula: C₁₃H₁₃N₃O₂

Purity: >98.0%(T)(HPLC)

Color and Shape: White to Light yellow to Light orange powder to crystalline

Molecular weight: 243.27

Ref: 3B-A2617

4-(4-Aminophenoxy)-N-methylpicolinamide

CAS: 284462-37-9

Formula: C₁₃H₁₃N₃O₂

Purity: 98%

Color and Shape: Solid

Molecular weight: 243.266

Ref: 10-F077869

2-Pyridinecarboxamide, 4-(4-aminophenoxy)-N-methyl-

CAS: 284462-37-9

Formula: C₁₃H₁₃N₃O₂

Purity: 97%

Color and Shape: Solid

Molecular weight: 243.2612

Ref: IN-DA00I5C4

Sorafenib EP Impurity A

CAS: 284462-37-9

Formula: C₁₃H₁₃N₃O₂

Color and Shape: Grey Solid

Molecular weight: 243.27

Ref: 4Z-S-2732

4-(4-Aminophenoxy)-N-methylpyridine-2-carboxamide

CAS: 284462-37-9

4-(4-Aminophenoxy)-N-methylpyridine-2-carboxamide

Purity: 98%

Color and Shape: Powder

Molecular weight: 243.26g/mol

Ref: 54-OR303782

[4-(4-Aminophenoxy)(2-pyridyl)]-N-methylcarboxamide

Controlled Product

CAS: 284462-37-9

Formula: C₁₃H₁₃N₃O₂

Color and Shape: Light Brown

Molecular weight: 243.26

Ref: TR-A618940

[4-(4-Aminophenoxy)(2-pyridyl)]-N-methylcarboxamide-d4

Controlled Product

CAS: 284462-37-9

Applications [4-(4-Aminophenoxy)(2-pyridyl)]-N-methylcarboxamide-d4 is an intermediate in the synthesis of Sorafenib-d4 (S676853); a labelled version of Sorafenib (S676850), a potent RAF kinase inhibitor.
References Richly, H., et al.: Int. J. Clin. Pharmacol. Ther., 41, 620 (2003);Khire, U.R., et al.: Bioorg. Med. Chem. Lett., 14, 783 (2004);Wilhelm, S.M., et al.: Cancer Res., 64, 7099 (2004);Rini, B.I., et al.: Expert Opin. Pharmacother., 7, 453 (2006)

Formula: C₁₃D₄H₉N₃O₂

Color and Shape: Neat

Molecular weight: 247.286

Ref: TR-A618944

[4-(4-Aminophenoxy)(2-pyridyl)]-N-methylcarboxamide

CAS: 284462-37-9

4-(4-Aminophenoxy)(2-pyridyl)]-N-methylcarboxamide is a chemical compound that inhibits the growth of cancer cells by binding to the active site of b-raf and blocking its activity. It has been shown in a pharmacokinetics study that 4-(4-aminophenoxy)(2-pyridyl)]-N-methylcarboxamide is absorbed rapidly through the oral administration, excreted in urine, and eliminated rapidly from the body. The optimal reaction for this drug was found to be at pH 7.0 with an ionic strength of 0.1 M (sodium chloride). This drug also has significant inhibitory activities against human cervical carcinoma and breast cancer cell lines (MDA-MB-231).

Formula: C₁₃H₁₃N₃O₂

Purity: Min. 95%

Color and Shape: Off-White To Beige To Light Brown Solid

Molecular weight: 243.26 g/mol

Ref: 3D-FA17813

Sorafenib EP Impurity A

CAS: 284462-37-9

Formula: C₁₃H₁₃N₃O₂

Molecular weight: 243.27

Ref: ST-EA-CP-S16001