CAS 28459-40-7
:10-Formyl-7,8-dihydrofolic acid
Description:
10-Formyl-7,8-dihydrofolic acid, with the CAS number 28459-40-7, is a derivative of folic acid, which is a vital B-vitamin (B9) involved in various biological processes, particularly in the synthesis of nucleic acids and amino acids. This compound features a formyl group at the 10-position of the pteridine ring, which distinguishes it from other folate derivatives. It is typically characterized by its role as an intermediate in the metabolism of folate and is involved in the one-carbon metabolism pathway. The compound is soluble in water and exhibits stability under physiological conditions, although it can be sensitive to light and heat. Its biological activity is primarily linked to its ability to participate in enzymatic reactions, particularly those catalyzed by enzymes like formyltetrahydrofolate synthetase. Due to its structural similarities to other folate derivatives, it may also exhibit competitive inhibition in certain enzymatic pathways. Overall, 10-Formyl-7,8-dihydrofolic acid is significant in biochemistry and pharmacology, particularly in the context of cellular metabolism and therapeutic applications.
Formula:C20H21N7O7
InChI:InChI=1S/C20H21N7O7/c21-20-25-16-15(18(32)26-20)23-11(7-22-16)8-27(9-28)12-3-1-10(2-4-12)17(31)24-13(19(33)34)5-6-14(29)30/h1-4,9,13H,5-8H2,(H,24,31)(H,29,30)(H,33,34)(H4,21,22,25,26,32)/t13-/m0/s1
InChI key:InChIKey=UXFQDXABPXWSTK-ZDUSSCGKSA-N
SMILES:O=C1C2=C(NCC(CN(C=O)C3=CC=C(C(N[C@@H](CCC(O)=O)C(O)=O)=O)C=C3)=N2)NC(N)=N1
Synonyms:- L-Glutamic acid, N-[4-[[(2-amino-1,4,7,8-tetrahydro-4-oxo-6-pteridinyl)methyl]formylamino]benzoyl]-
- N-Formyl-7,8-dihydrofolic acid
- N-[4-[[(2-Amino-3,4,7,8-tetrahydro-4-oxo-6-pteridinyl)methyl]formylamino]benzoyl]-L-glutamic acid
- Glutamic acid, N-[p-[N-[(2-amino-7,8-dihydro-4-hydroxy-6-pteridinyl)methyl]formamido]benzoyl]-
- L-Glutamic acid, N-[4-[[(2-amino-3,4,7,8-tetrahydro-4-oxo-6-pteridinyl)methyl]formylamino]benzoyl]-
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Found 5 products.
10-Formyldihydrofolate
CAS:<p>10-Formyldihydrofolate is a Methotrexate metabolite. It inhibits thymidylate synthetase and glycinamide ribotide transformylase.</p>Formula:C20H21N7O7Color and Shape:SolidMolecular weight:471.4310-Formyl-7,8-dihydro Folic Acid Disodium (>85%)
CAS:<p>Stability Temperature Sensitive<br>Applications 10-Formyl-7,8-dihydrofolic acid is a novel folate found in methotrexate-treated cells. 10-Formyldihydrofolate (H2folate) has not been found as a component of intracellular folates in normal tissues but has been identified in the cytosol of methotrexate (MTX)-treated MCF-7 breast cancer cells and normal human myeloid precursor cells.<br>References Barford, P.A., et al.: Br. J. Cancer, 1978, 38, 122 (1978); Baggott, J.E., et al.: Biochemistry, 1979, 18, 1036 (1979); Hahm, S., et al.: Biochemistry, 33, 1473 (1994),<br></p>Formula:C20H19N7O7·2NaColor and Shape:NeatMolecular weight:515.39
