CAS 284665-11-8

N-(9-fluorenylmethoxycarbonyl)glycine-2,2-D2

Description:

N-(9-fluorenylmethoxycarbonyl)glycine-2,2-D2, commonly referred to as Fmoc-Gly-D2, is a derivative of glycine where the amino group is protected by the 9-fluorenylmethoxycarbonyl (Fmoc) group, and the hydrogen atoms on the alpha carbon are replaced with deuterium isotopes. This compound is primarily used in peptide synthesis, particularly in solid-phase peptide synthesis (SPPS), where the Fmoc group serves as a protective group that can be easily removed under basic conditions. The incorporation of deuterium can be beneficial for various applications, including NMR spectroscopy and metabolic studies, as it provides a means to trace the compound in biological systems. The presence of the Fmoc group enhances the solubility and stability of the amino acid during synthesis. Overall, Fmoc-Gly-D2 is a valuable tool in the field of organic and medicinal chemistry, facilitating the development of peptides with specific isotopic labeling for research and therapeutic purposes.

Fmoc-[D₂]Gly-OH

CAS: 284665-11-8

Bachem ID: 4071076.

Formula: C₁₇H₁₃D₂NO₄

Purity: > 95%

Molecular weight: 299.33

Ref: 01-4071076

Glycine-2,2-d2-N-FMOC

CAS: 284665-11-8

Formula: HOOCCD₂NHFMOC

Purity: 98 atom % D

Color and Shape: White Solid

Molecular weight: 299.32

Ref: 3U-D5589

N-Fmoc-glycine-d2

Controlled Product

CAS: 284665-11-8

Applications Isotope labelled N-Fmoc-glycine is an N-Fmoc-protected form of Glycine (G615990). Glycine is a nonessential amino acid that acts as an inhibitory neyrotransmitter in the vertebrate central nervous system. Glycine also posesses cytoprotective against oxidant damage in the kidney.
References Eulenberg, V., et al.: Trend. Biochem. Sci., 30, 325 (2005); Gundersen, R., et al.: Acta Anaesth. Scand., 49, 1108 (2005); Lockart, R. & Eagle, H.: Science, 129, 252 (1959); Sogabe, K., et al.: Kidn. Int., 50, 845 (1996)

Formula: C₁₇H₁₃D₂NO₄

Color and Shape: Neat

Molecular weight: 299.32

Ref: TR-F632502

Fmoc-[D2]Gly-OH

Controlled Product

CAS: 284665-11-8

Fmoc-Gly is a synthetic amino acid that has been used in the synthesis of peptides and proteins. The Fmoc group is removed by an amidase to yield the desired peptide. Fmoc-gly can be quantified using matrix-assisted laser desorption/ionization mass spectrometry (MALDI-TOF). This technique is also used for the analysis of cellular uptake, intracellular localization, and metabolic stability. A laser is used to vaporize a sample and create ions. These ions are then analyzed with a mass spectrometer to generate a spectrum that can be matched with a database of known compounds. MALDI-TOF has been shown to be more efficient than other methods for peptide analysis such as electrospray ionization.

Formula: C₁₇H₁₃D₂NO₄

Purity: Min. 95%

Molecular weight: 299.32 g/mol

Ref: 3D-FF111393