Nampt activator-4, identified by its CAS number 2847156-05-0, is a chemical compound that functions as a small molecule modulator of the enzyme nicotinamide phosphoribosyltransferase (Nampt). This enzyme plays a crucial role in the NAD+ biosynthesis pathway, which is essential for cellular metabolism and energy production. The compound is characterized by its ability to enhance Nampt activity, potentially leading to increased levels of NAD+ in cells. This modulation can have significant implications for various biological processes, including metabolism, aging, and cellular stress responses. Nampt activator-4 is of interest in research related to metabolic disorders, neurodegenerative diseases, and age-related conditions, as it may promote cellular health and longevity. Its chemical structure and specific interactions with biological targets are subjects of ongoing investigation, aiming to elucidate its therapeutic potential and mechanisms of action. As with many small molecule activators, understanding its pharmacokinetics, bioavailability, and safety profile is essential for potential applications in clinical settings.

Nampt activator-4

2847156-05-0: Nampt activator-4, identified by its CAS number 2847156-05-0, is a chemical compound that functions as a small molecule modulator of the enzyme nicotinamide phosphoribosyltransferase (Nampt). This enzyme plays a crucial role in the NAD+ biosynthesis pathway, which is essential for cellular metabolism and energy production. The compound is characterized by its ability to enhance Nampt activity, potentially leading to increased levels of NAD+ in cells. This modulation can have significant implications for various biological processes, including metabolism, aging, and cellular stress responses. Nampt activator-4 is of interest in research related to metabolic disorders, neurodegenerative diseases, and age-related conditions, as it may promote cellular health and longevity. Its chemical structure and specific interactions with biological targets are subjects of ongoing investigation, aiming to elucidate its therapeutic potential and mechanisms of action. As with many small molecule activators, understanding its pharmacokinetics, bioavailability, and safety profile is essential for potential applications in clinical settings.

Nampt activator-4, a positive allosteric modulator (N-PAM) of nicotinamide phosphoribosyltransferase (NAMPT), has an EC50 of 0.058 μM and can enhance nicotinamide adenine dinucleotide (NAD+) levels in cells [1].

CAS 2847156-05-0

Nampt activator-4

Nampt activator-4

Ref: TM-T86957