HPK1-IN-42, identified by its CAS number 2848684-50-2, is a chemical compound that serves as an inhibitor of the HPK1 (Hemopoietic Progenitor Kinase 1) enzyme, which is involved in various cellular signaling pathways, particularly those related to immune responses. This compound is characterized by its potential therapeutic applications in oncology and immunology, as inhibiting HPK1 may enhance T-cell activation and improve anti-tumor immunity. Structurally, HPK1-IN-42 features specific functional groups that contribute to its binding affinity and selectivity for the HPK1 target. The compound is typically evaluated for its pharmacokinetic properties, including absorption, distribution, metabolism, and excretion (ADME), to assess its viability as a drug candidate. Additionally, studies may focus on its efficacy and safety profile in preclinical models. As research progresses, HPK1-IN-42 may provide insights into novel treatment strategies for diseases where HPK1 plays a critical role.

HPK1-IN-42

2848684-50-2: HPK1-IN-42, identified by its CAS number 2848684-50-2, is a chemical compound that serves as an inhibitor of the HPK1 (Hemopoietic Progenitor Kinase 1) enzyme, which is involved in various cellular signaling pathways, particularly those related to immune responses. This compound is characterized by its potential therapeutic applications in oncology and immunology, as inhibiting HPK1 may enhance T-cell activation and improve anti-tumor immunity. Structurally, HPK1-IN-42 features specific functional groups that contribute to its binding affinity and selectivity for the HPK1 target. The compound is typically evaluated for its pharmacokinetic properties, including absorption, distribution, metabolism, and excretion (ADME), to assess its viability as a drug candidate. Additionally, studies may focus on its efficacy and safety profile in preclinical models. As research progresses, HPK1-IN-42 may provide insights into novel treatment strategies for diseases where HPK1 plays a critical role.

<p>HPK1-IN-42 (compound 185) is an inhibitor of HPK1, displaying potent activity with an IC50 of 0.24 nM [1].</p>

CAS 2848684-50-2

HPK1-IN-42

HPK1-IN-42

Ref: TM-T86591