AT1R antagonist 1, identified by its CAS number 2848719-80-0, is a chemical compound that functions primarily as an antagonist of the angiotensin II type 1 receptor (AT1R). This receptor is involved in various physiological processes, including blood pressure regulation and fluid balance. The compound is characterized by its ability to inhibit the action of angiotensin II, a peptide hormone that can lead to vasoconstriction and increased blood pressure. As an AT1R antagonist, it may have potential therapeutic applications in treating conditions such as hypertension and heart failure. The molecular structure of AT1R antagonist 1 typically includes specific functional groups that facilitate its binding to the AT1 receptor, thereby blocking its activity. Additionally, the compound may exhibit favorable pharmacokinetic properties, such as oral bioavailability and a suitable half-life, which are essential for its efficacy in clinical settings. Overall, AT1R antagonist 1 represents a significant area of interest in cardiovascular pharmacology and drug development.

AT1R antagonist 1

2848719-80-0: AT1R antagonist 1, identified by its CAS number 2848719-80-0, is a chemical compound that functions primarily as an antagonist of the angiotensin II type 1 receptor (AT1R). This receptor is involved in various physiological processes, including blood pressure regulation and fluid balance. The compound is characterized by its ability to inhibit the action of angiotensin II, a peptide hormone that can lead to vasoconstriction and increased blood pressure. As an AT1R antagonist, it may have potential therapeutic applications in treating conditions such as hypertension and heart failure. The molecular structure of AT1R antagonist 1 typically includes specific functional groups that facilitate its binding to the AT1 receptor, thereby blocking its activity. Additionally, the compound may exhibit favorable pharmacokinetic properties, such as oral bioavailability and a suitable half-life, which are essential for its efficacy in clinical settings. Overall, AT1R antagonist 1 represents a significant area of interest in cardiovascular pharmacology and drug development.

<p>AT1R Antagonist 1 (compound 10) serves as a potent, selective ligand for AT1R with considerable affinity, demonstrated by a K i value of 8.5 nM [1].</p>

CAS 2848719-80-0

AT1R antagonist 1

AT1R antagonist 1

Ref: TM-T72606