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CAS 28516-86-1

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5′-Adenylic acid, 2′-O-methyl-, homopolymer

Description:
5′-Adenylic acid, 2′-O-methyl-, homopolymer, commonly referred to as 2′-O-methylated RNA, is a synthetic polymer derived from adenosine monophosphate (AMP) with specific modifications that enhance its stability and biological activity. This substance features a backbone composed of ribonucleotides, where the 2′-hydroxyl group of the ribose sugar is methylated, providing resistance to enzymatic degradation. The polymer exhibits characteristics typical of nucleic acids, including the ability to form secondary structures such as hairpins and loops, which can influence its interactions with proteins and other nucleic acids. Its unique modifications make it particularly useful in various biotechnological applications, including RNA therapeutics, gene silencing, and as a component in vaccine development. Additionally, the 5′-phosphate group is crucial for its recognition by cellular machinery, facilitating processes such as translation and transcription. Overall, this homopolymer is significant in molecular biology and therapeutic contexts due to its enhanced stability and functional versatility.
Formula:(C11H16N5O7P)x
InChI:InChI=1S/C11H16N5O7P/c1-21-8-7(17)5(2-22-24(18,19)20)23-11(8)16-4-15-6-9(12)13-3-14-10(6)16/h3-5,7-8,11,17H,2H2,1H3,(H2,12,13,14)(H2,18,19,20)/t5-,7-,8-,11-/m1/s1
InChI key:InChIKey=TVGFEBXIZUYVFR-IOSLPCCCSA-N
SMILES:O(C)[C@H]1[C@@H](O[C@H](COP(=O)(O)O)[C@H]1O)N2C=3C(N=C2)=C(N)N=CN3
Synonyms:
  • Poly(2′-O-methyladenylic acid)
  • Adenosine, 2′-O-methyl-, 5′-(dihydrogen phosphate), polymers
  • Poly(2′-O-methyladenylate)
  • 2′-O-Methyladenine oligonucleotides
  • 5′-Adenylic acid, 2′-O-methyl-, homopolymer
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