CAS 28541-83-5

4-Methylumbelliferyl α-D-mannopyranoside

Description:

4-Methylumbelliferyl α-D-mannopyranoside (CAS 28541-83-5) is a synthetic glycoside commonly used as a substrate in enzymatic assays, particularly for the detection of α-mannosidase activity. This compound features a 4-methylumbelliferone moiety, which is a fluorescent marker, linked to an α-D-mannopyranoside unit. Its structure allows for the release of 4-methylumbelliferone upon hydrolysis by specific enzymes, resulting in a measurable fluorescence that can be quantified. The substance is typically a white to off-white powder and is soluble in water and organic solvents, making it versatile for laboratory applications. It is stable under normal conditions but should be stored in a cool, dry place to maintain its integrity. The fluorescence emitted upon enzymatic cleavage makes it a valuable tool in biochemical research, particularly in studies involving carbohydrate metabolism and enzyme kinetics. Safety data sheets should be consulted for handling and disposal guidelines, as with any chemical reagent.

Formula: C₁₆H₁₈O₈

InChI: InChI=1S/C16H18O8/c1-7-4-12(18)23-10-5-8(2-3-9(7)10)22-16-15(21)14(20)13(19)11(6-17)24-16/h2-5,11,13-17,19-21H,6H2,1H3/t11-,13-,14+,15+,16+/m1/s1

InChI key: InChIKey=YUDPTGPSBJVHCN-VMMWWAARSA-N

SMILES: CC=1C=2C(=CC(O[C@H]3O[C@H](CO)[C@@H](O)[C@H](O)[C@@H]3O)=CC2)OC(=O)C1

Synonyms:

• 7-(α-D-Mannopyranosyloxy)-4-methyl-2H-1-benzopyran-2-one
• 4-Methylumbelliferyl α-D-mannoside
• 2H-1-Benzopyran-2-one, 7-(α-D-mannopyranosyloxy)-4-methyl-
• 4-Methylumbelliferyl α-D-mannopyranoside
• Mannopyranoside, 4-methyl-2-oxo-2H-1-benzopyran-7-yl, α-D-

2H-1-Benzopyran-2-one, 7-(α-D-mannopyranosyloxy)-4-methyl-

CAS: 28541-83-5

Formula: C₁₆H₁₈O₈

Purity: 97%

Color and Shape: Solid

Molecular weight: 338.3093

Ref: IN-DA002VOE

4-Methylumbelliferyl a-D-mannopyranoside

CAS: 28541-83-5

Formula: C₁₆H₁₈O₈

Molecular weight: 338.30

Ref: 7W-GC6981

4-Methylumbelliferyl α-D-Mannopyranoside

CAS: 28541-83-5

Formula: C₁₆H₁₈O₈

Purity: >97.0%(HPLC)

Color and Shape: White to Almost white powder to crystal

Molecular weight: 338.31

Ref: 3B-M3023

4-Methylumbelliferyl-α-D-mannopyranoside

CAS: 28541-83-5

4-Methylumbelliferyl-α-D-mannopyranoside

Formula: C₁₆H₁₈O₈

Purity: By hplc: >99% (Typical Value in Batch COA)

Color and Shape: white crystalline powder

Molecular weight: 338.31g/mol

Ref: 54-BIM1100

4-Methylumbelliferyl a-D-Mannopyranoside

CAS: 28541-83-5

Stability Hygroscopic
Applications A substrate for mannosidase.

Formula: C₁₆H₁₈O₈

Color and Shape: Neat

Molecular weight: 338.31

Ref: TR-M334745

4-Methylumbelliferyl a-D-mannopyranoside

CAS: 28541-83-5

4-Methylumbelliferyl alpha-D-mannopyranoside (4-MU-a-D-Man) is a fluorogenic substrate used in activity assays for alpha-mannosidase. When it is hydrolyzed by alpha-mannosidase, it produces a fluorescent compound, 4-methylumbelliferone (4-MU). 4-MU-a-D-Man is often used in medical research to monitor the activity of alpha-mannosidase, which is important in lysosomal storage diseases.  In addition, 4-Methylumbelliferyl alpha-D-mannopyranoside has been used to study the the activity of concanavalin A, a lectin that specifically binds to alpha-D-mannopyranosyl and alpha-D-glucopyranosyl residues on various glycoproteins. The use of this fluorogenic enzyme substrate permits study the degree of alpha-D-mannosidic linkage cleavage by the enzyme.

Formula: C₁₆H₁₈O₈

Purity: Min. 98 Area-%

Color and Shape: White Off-White Powder

Molecular weight: 338.31 g/mol

Ref: 3D-EM03179

4-Methylumbelliferyl-α-D-mannopyranoside

CAS: 28541-83-5

4-Methylumbelliferyl alpha-D-mannopyranoside (4-MU-a-D-Man) is a fluorogenic substrate used in activity assays for alpha-mannosidase. When it is hydrolyzed by alpha-mannosidase, it produces a fluorescent compound, 4-methylumbelliferone (4-MU). 4-MU-a-D-Man is often used in medical research to monitor the activity of alpha-mannosidase, which is important in lysosomal storage diseases.  In addition, 4-Methylumbelliferyl alpha-D-mannopyranoside has been used to study the the activity of concanavalin A, a lectin that specifically binds to alpha-D-mannopyranosyl and alpha-D-glucopyranosyl residues on various glycoproteins. The use of this fluorogenic enzyme substrate permits study the degree of alpha-D-mannosidic linkage cleavage by the enzyme.

Formula: C₁₆H₁₈O₈

Purity: Min. 98 Area-%

Molecular weight: 338.32 g/mol

Ref: 3D-M-5730

GC-204

CAS: 28541-83-5

GC-204 is a selective inhibitor of carbonic anhydrase ix (caix)

Formula: C₁₆H₁₈O₈

Color and Shape: Solid

Molecular weight: 338.31

Ref: TM-T71877