CAS 286013-13-6

1,4-bis(trifluoromethyl)benzene-ring-13C6

Description:

1,4-bis(trifluoromethyl)benzene-ring-13C6, with the CAS number 286013-13-6, is a chemically modified aromatic compound characterized by the presence of two trifluoromethyl groups (-CF3) attached to a benzene ring. The incorporation of these highly electronegative trifluoromethyl groups significantly enhances the compound's lipophilicity and alters its electronic properties, making it useful in various applications, including pharmaceuticals and agrochemicals. The "ring-13C6" designation indicates that the compound is isotopically labeled with carbon-13, which is often utilized in NMR spectroscopy for structural elucidation and tracking metabolic pathways. This compound is typically stable under standard conditions but may undergo reactions typical of aromatic compounds, such as electrophilic substitution. Its unique properties, including high thermal stability and low reactivity, make it an interesting subject for research in materials science and organic synthesis. Safety data should be consulted for handling, as the trifluoromethyl groups can impart toxicity and environmental concerns.

1,4-Bis(trifluoromethyl)benzene-13C6

Controlled Product

CAS: 286013-13-6

Applications 1,4-Bis(trifluoromethyl)benzene-13C6 is an intermediate in the synthesis of Dutasteride-13C6 (D735002), which is a labeled Dutasteride (D735000). Dutasteride is a dual inhibitor of 5α-reductase isoenzymes type 1 and 2; structurally related to Finasteride (F342000). Dutasteride is used in the treatment of benign prostatic hyperplasia.
References Bakshi, R.K., et al.: J. Med. Chem., 38, 3189 (1995), Gisleskog, P.O., et al.: Brit. J. Clin. Pharmacol., 47, 53 (1999), Djavan, B., et al.: Expert Opin. Pharmacother., 6, 311 (2005),

Formula: C₆C₂H₄F₆

Color and Shape: Neat

Molecular weight: 220.064

Ref: TR-F588742