CAS 28643-80-3

Sodium nigericin

Description:

Sodium nigericin is a potassium ionophore, primarily known for its ability to facilitate the transport of potassium ions across biological membranes. It is derived from the fermentation of certain Streptomyces species and is often used in biochemical research to study ion transport and cellular processes. This compound exhibits a unique structure that allows it to form complexes with potassium ions, effectively enabling their movement through lipid bilayers. Sodium nigericin is typically utilized in various laboratory applications, including studies on membrane potential and cellular signaling. It is important to note that while it is valuable in research, it can also exhibit cytotoxic effects at higher concentrations, necessitating careful handling and usage. Additionally, its mechanism of action involves disrupting ionic gradients, which can have significant implications for cellular homeostasis. Overall, sodium nigericin serves as a crucial tool in the field of biochemistry, particularly in the exploration of ion transport mechanisms and their physiological relevance.

Formula: C₄₀H₆₈O₁₁·Na

InChI: InChI=1S/C40H68O11.Na/c1-21-11-12-28(46-33(21)26(6)36(42)43)17-29-18-30(45-10)27(7)40(48-29)25(5)19-38(9,51-40)32-13-14-37(8,49-32)35-23(3)16-31(47-35)34-22(2)15-24(4)39(44,20-41)50-34;/h21-35,41,44H,11-20H2,1-10H3,(H,42,43);/t21-,22-,23-,24+,25+,26+,27+,28+,29+,30+,31+,32+,33+,34-,35+,37-,38-,39-,40+;/m0./s1

InChI key: InChIKey=JDJBSPPSXYLDJN-PDEFJWSRSA-N

SMILES: C[C@H]1[C@]2(O[C@@](C)(C1)[C@@]3(O[C@@](C)(CC3)[C@@]4(O[C@](C[C@@H]4C)([C@]5(O[C@](CO)(O)[C@H](C)C[C@@H]5C)[H])[H])[H])[H])O[C@H](C[C@@H]6O[C@@]([C@H](C(O)=O)C)([C@@H](C)CC6)[H])C[C@@H](OC)[C@H]2C.[Na]

Synonyms:

• 1,6-Dioxaspiro[4.5]decane, nigericin deriv.
• 2-{6-[(2-{5'-[6-hydroxy-6-(hydroxymethyl)-3,5-dimethyltetrahydro-2H-pyran-2-yl]-2,3'-dimethyloctahydro-2,2'-bifuran-5-yl}-9-methoxy-2,4,10-trimethyl-1,6-dioxaspiro[4.5]dec-7-yl)methyl]-3-methyltetrahydro-2H-pyran-2-yl}propanoic acid
• NSC 292567
• Nigericin, monosodium salt
• Nigericin, sodium salt (1:1)
• Sodium (2R)-2-[(3S,6R)-6-[[(2S,4R,5R,7R,9R,10R)-2-[(5S)-5-[(2R,3S,5R)-5-[(2S,3S,5R,6R)-6-hydroxy-6-(hydroxymethyl)-3,5-dimethyloxan-2-yl]-3-methyloxolan-2-yl]-5-methyloxolan-2-yl]-9-methoxy-2,4,10-trimethyl-1,6-dioxaspiro[4.5]decan-7-yl]methyl]-3-methyloxan-2-yl]propanoate
• Sodium nigericin
• sodium 2-[(3S,6R)-6-{[(5R,7R,9R,10S)-2-{(3'S,5'R)-5'-[(2S,3S,5R,6R)-6-hydroxy-6-(hydroxymethyl)-3,5-dimethyltetrahydro-2H-pyran-2-yl]-2,3'-dimethyloctahydro-2,2'-bifuran-5-yl}-9-methoxy-2,4,10-trimethyl-1,6-dioxaspiro[4.5]dec-7-yl]methyl}-3-methyltetrahydro-2H-pyran-2-yl]propanoate
• Nigericin sodium salt

Nigericin sodium salt, 98+%

CAS: 28643-80-3

A potassium ionophore

Formula: C₄₀H₆₇NaO₁₁

Purity: 98+%

Color and Shape: White to pale yellow, Powder

Molecular weight: 746.96

Ref: 02-J61349

Nigericin, sodium salt (1:1)

CAS: 28643-80-3

Formula: C₄₀H₆₇NaO₁₁

Purity: 98%

Color and Shape: Solid

Molecular weight: 746.9432

Ref: IN-DA002VYS

Nigericin sodium salt

CAS: 28643-80-3

Nigericin sodium salt

Purity: ≥98%

Molecular weight: 746.94g/mol

Ref: 54-BUP03598

Nigericin sodium salt

CAS: 28643-80-3

Nigericin sodium salt

Formula: C₄₀H₆₇O₁₁·Na

Purity: By hplc: 100% (Typical Value in Batch COA)

Color and Shape: white powder

Molecular weight: 746.94g/mol

Ref: 54-BIN0112

Nigericin sodium salt

CAS: 28643-80-3

Formula: C₄₀H₆₇NaO₁₁

Purity: ≥ 98%

Color and Shape: White to off-white powder

Molecular weight: 746.94

Ref: 7W-GA6233

Nigericin sodium salt

CAS: 28643-80-3

Nigericin sodium salt, an antibiotic and NLRP3 activator from S. hygroscopicus, inhibits Golgi and gram-positive bacteria, blocking viral activation.

Formula: C₄₀H₆₇NaO₁₁

Purity: 98.2% - 99.52%

Color and Shape: Solid

Molecular weight: 746.94

Ref: TM-T3092

Nigericin Sodium Salt

CAS: 28643-80-3

Stability Hygroscopic
Applications Nigericin Sodium Salt is a polyether antibioitc K+ and Na+ ionophore.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Graven, S.N., et al.: Proc. Natl. Acad. Sci., 56, 654-8 (1966);

Formula: C₄₀H₆₇NaO₁₁

Color and Shape: White To Off-White

Molecular weight: 746.94

Ref: TR-N598523

Nigericin sodium - from Streptomyces hygroscopicus

CAS: 28643-80-3

Membrane pore-forming agent; H+, K+, Pb2+ ionophore; polyether antibiotic

Formula: C₄₀H₆₇O₁₁Na

Purity: Min. 95%

Color and Shape: White Powder

Molecular weight: 746.94 g/mol

Ref: 3D-FN46958

Nigericin sodium

CAS: 28643-80-3

Nigericin transports cations across the membrane of the cell and it is used to study anion transport. It can be used as a buffer to control pH value inside of the cell.

Formula: C₄₀H₆₇NaO₁₁

Purity: Min. 95%

Molecular weight: 746.94 g/mol

Ref: 3D-AN34907