CAS 286456-42-6

3-(2,5-Difluorophenyl)-7-(1,1-dimethylethyl)-6-[(1-methyl-1H-1,2,4-triazol-5-yl)methoxy]-1,2,4-triazolo[4,3-b]pyridazine

Description:

The chemical substance known as 3-(2,5-Difluorophenyl)-7-(1,1-dimethylethyl)-6-[(1-methyl-1H-1,2,4-triazol-5-yl)methoxy]-1,2,4-triazolo[4,3-b]pyridazine, with the CAS number 286456-42-6, is a synthetic compound that belongs to the class of triazolopyridazines. This compound features a complex molecular structure characterized by the presence of a triazole ring fused to a pyridazine moiety, which contributes to its potential biological activity. The presence of difluorophenyl and tert-butyl groups enhances its lipophilicity and may influence its pharmacokinetic properties. Additionally, the methoxy group linked to a triazole moiety suggests potential interactions with biological targets, making it of interest in medicinal chemistry. Such compounds are often investigated for their potential therapeutic applications, including antifungal, antibacterial, or anticancer activities. The specific characteristics, such as solubility, stability, and reactivity, would depend on the molecular interactions and the environment in which the compound is studied.

Formula: C₁₉H₁₉F₂N₇O

InChI: InChI=1S/C19H19F2N7O/c1-19(2,3)13-8-15-24-25-17(12-7-11(20)5-6-14(12)21)28(15)26-18(13)29-9-16-22-10-23-27(16)4/h5-8,10H,9H2,1-4H3

InChI key: InChIKey=BQDUNOMMYOKHEP-UHFFFAOYSA-N

SMILES: O(CC=1N(C)N=CN1)C2=NN3C(=NN=C3C=C2C(C)(C)C)C4=C(F)C=CC(F)=C4

Synonyms:

• 3-(2,5-Difluorophenyl)-7-(1,1-dimethylethyl)-6-[(1-methyl-1H-1,2,4-triazol-5-yl)methoxy]-1,2,4-triazolo[4,3-b]pyridazine
• 1,2,4-Triazolo[4,3-b]pyridazine, 3-(2,5-difluorophenyl)-7-(1,1-dimethylethyl)-6-[(1-methyl-1H-1,2,4-triazol-5-yl)methoxy]-
• L 838417

5-({[7-tert-butyl-3-(2,5-difluorophenyl)-[1,2,4]triazolo[4,3-b]pyridazin-6-yl]oxy}methyl)-1-methyl-1,2,4-triazole

CAS: 286456-42-6

Formula: C₁₉H₁₉F₂N₇O

Purity: 95%

Color and Shape: Solid

Molecular weight: 399.3973

Ref: IN-DA002VZ5

L-838417

CAS: 286456-42-6

L-838417

Purity: ≥98%

Molecular weight: 399.4g/mol

Ref: 54-BUP02606

L-838417

Controlled Product

CAS: 286456-42-6

Applications L-838417 is an anxiolytic agent and a selective GABAA receptor partial agonist that selectively binds to α1, α2, α3 and α5 subunits (1,2). It also exhibits antinociceptive and anti-inflammatory properties.
References (1) Knabl, J., et al.: Nature. 451, 330 (2008) (2) Johnston, G.A.R., et al.: Curr. Pharm. Design, 11, 1867 (2005)

Formula: C₁₉H₁₉F₂N₇O

Color and Shape: Neat

Molecular weight: 399.40

Ref: TR-L838417

L 838417

CAS: 286456-42-6

Selective partial GABAA receptor antagonist of subtypes  α1, α2, α3, α5 subunits. Non-sedative anxiolytic effects demonstrated in vivo, without compromising motor activity. Anti-nociceptive and anti-inflammatory activities also demonstrated in vivo.

Formula: C₁₉H₁₉F₂N₇O

Purity: Min. 95%

Color and Shape: White/Off-White Solid

Molecular weight: 399.16191

Ref: 3D-FD24821

L-838417

CAS: 286456-42-6

L-838417 is a GABAA receptor subtype-selective benzodiazepine site-selective ligand and GABAA receptor-positive modulator used in the study of anxiety disorders

Formula: C₁₉H₁₉F₂N₇O

Purity: 98.12% - 99.70%

Color and Shape: Solid

Molecular weight: 399.4

Ref: TM-T19702