CAS 286942-97-0: Ezatiostat hydrochloride

Description: Ezatiostat hydrochloride, with the CAS number 286942-97-0, is a small molecule compound primarily studied for its potential therapeutic applications, particularly in the treatment of certain hematological malignancies. It functions as a selective inhibitor of the enzyme glutathione S-transferase P1-1 (GSTP1-1), which is involved in cellular detoxification processes. This inhibition can lead to increased levels of reactive oxygen species (ROS) within cancer cells, promoting apoptosis and enhancing the efficacy of other chemotherapeutic agents. Ezatiostat hydrochloride is typically administered in a hydrochloride salt form, which enhances its solubility and stability in aqueous solutions. The compound has been evaluated in clinical settings for its ability to improve outcomes in patients with conditions such as acute myeloid leukemia (AML) and myelodysplastic syndromes (MDS). Its pharmacological profile includes considerations of bioavailability, metabolism, and potential side effects, which are critical for determining its therapeutic window and overall safety in clinical use.

Formula: C₂₇H₃₅N₃O₆SHCl

Synonyms:

• L-gamma-Glutamyl-S-(phenylmethyl)-L-cysteinyl-2-phenylglycine diethyl ester monohydrochloride

Glycine, L-γ-glutamyl-S-(phenylmethyl)-L-cysteinyl-2-phenyl-, 1,3-diethyl ester, hydrochloride (1:1), (2R)-

CAS: 286942-97-0

• Formula: C₂₇H₃₆ClN₃O₆S
• Molecular weight: 566.1092

Ezatiostat hydrochloride

CAS: 286942-97-0

Ezatiostat HCl (TLK199) inhibits glutathione S-transferase, GSTP1-1 specifically, and may treat cytopenias.

• Formula: C₂₇H₃₆ClN₃O₆S
• Purity: 98%
• Color and Shape: Solid
• Molecular weight: 566.11

EzatiostatHydrochloride

CAS: 286942-97-0

Ezatiostat is a small molecule that inhibits the methyltransferase activity of DNA-dependent RNA polymerase. It …

• Formula: C₂₇H₃₆ClN₃O₆S
• Purity: Min. 95%
• Molecular weight: 566.11 g/mol