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CAS 287964-59-4

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Cyanotemozolomide

Description:
Cyanotemozolomide, identified by its CAS number 287964-59-4, is a chemical compound that belongs to the class of alkylating agents, specifically designed for use in cancer therapy. It is a derivative of temozolomide, which is commonly used in the treatment of glioblastoma and other brain tumors. The compound features a cyanide group, which may enhance its pharmacological properties. Cyanotemozolomide exhibits characteristics typical of alkylating agents, including the ability to form covalent bonds with DNA, leading to the disruption of DNA replication and ultimately inducing apoptosis in rapidly dividing cancer cells. Its mechanism of action involves the methylation of DNA at the O6 position of guanine, which is critical for its cytotoxic effects. The compound is typically administered orally and is known for its ability to cross the blood-brain barrier, making it particularly effective for central nervous system malignancies. As with many chemotherapeutic agents, its use may be associated with side effects, including myelosuppression and gastrointestinal disturbances, necessitating careful monitoring during treatment.
Formula:C6H4N6O
InChI:InChI=1/C6H4N6O/c1-11-6(13)12-3-8-4(2-7)5(12)9-10-11/h3H,1H3
SMILES:Cn1c(=O)n2cnc(C#N)c2nn1
Synonyms:
  • 3-Methyl-4-oxo-3,4-dihydroimidazo[5,1-d][1,2,3,5]tetrazine-8-carbonitrile
  • 3-Methyl-4-Oxo-Imidazo[5,1-D][1,2,3,5]Tetrazine-8-Carbonitrile
  • Imidazo[5,1-c][1,2,4]triazine-8-carboxamide
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