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CAS 28797-61-7

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Pirenzepine

Description:
Pirenzepine is a selective muscarinic antagonist primarily used in the treatment of peptic ulcers and gastrointestinal disorders. It operates by inhibiting the action of acetylcholine at muscarinic receptors, particularly the M1 subtype, which reduces gastric acid secretion and promotes gastric mucosal protection. This compound is characterized by its relatively high affinity for M1 receptors compared to other muscarinic receptor subtypes, which contributes to its therapeutic effects with fewer side effects associated with broader anticholinergic activity. Pirenzepine is typically administered orally and has a moderate bioavailability. Its pharmacokinetics involve hepatic metabolism, and it is excreted primarily through urine. The substance is known for its potential side effects, which may include dry mouth, blurred vision, and constipation, typical of anticholinergic agents. Overall, pirenzepine represents a significant advancement in the management of gastric conditions, highlighting the importance of selective receptor targeting in pharmacotherapy.
Formula:C19H21N5O2
InChI:InChI=1/C19H21N5O2/c1-22-9-11-23(12-10-22)13-17(25)24-16-7-3-2-5-14(16)19(26)21-15-6-4-8-20-18(15)24/h2-8H,9-13H2,1H3,(H,21,26)/p+2
InChI key:InChIKey=RMHMFHUVIITRHF-UHFFFAOYSA-N
SMILES:C(CN1CCN(C)CC1)(=O)N2C=3C(NC(=O)C=4C2=CC=CC4)=CC=CN3
Synonyms:
  • 5,11-Dihydro-11-[2-(4-methyl-1-piperazinyl)acetyl]-6H-pyrido[2,3-b][1,4]benzodiazepin-6-one
  • 6H-Pyrido[2,3-b][1,4]benzodiazepin-6-one, 5,11-dihydro-11-[2-(4-methyl-1-piperazinyl)acetyl]-
  • Pirenzepin
  • Pirenzepina
  • Pirenzepine
  • 6H-Pyrido[2,3-b][1,4]benzodiazepin-6-one, 5,11-dihydro-11-[(4-methyl-1-piperazinyl)acetyl]-
  • 11-[(4-methylpiperazin-1-yl)acetyl]-5,11-dihydro-6H-pyrido[2,3-b][1,4]benzodiazepin-6-one
  • 1-methyl-4-[2-oxo-2-(6-oxo-5,6-dihydro-11H-pyrido[2,3-b][1,4]benzodiazepin-11-yl)ethyl]piperazinediium
  • PIRENZEPINE DIHYDROCHLORIDE MONOHYDRATE
  • 11-((4-methyl-1-piperazinyl)acetyl)-5,11-dihydro-6h-pyrido(2,3-b)(1,4)benzod
  • See more synonyms
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